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Research ArticleNew Research, Disorders of the Nervous System

CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations

Lily M. Y. Yu, Denis Polygalov, Marie E. Wintzer, Ming-Ching Chiang and Thomas J. McHugh
eNeuro 10 February 2016, 3 (1) ENEURO.0003-16.2016; https://doi.org/10.1523/ENEURO.0003-16.2016
Lily M. Y. Yu
Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
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Denis Polygalov
Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
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Marie E. Wintzer
Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
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Ming-Ching Chiang
Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
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Thomas J. McHugh
Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0003-16.2016
PubMed 
27022627
Published By 
Society for Neuroscience
History 
  • Received January 4, 2016
  • Revision received January 29, 2016
  • Accepted February 1, 2016
  • Published online February 10, 2016.
Copyright & Usage 
Copyright © 2016 Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Lily M. Y. Yu,
  2. Denis Polygalov,
  3. Marie E. Wintzer,
  4. Ming-Ching Chiang and
  5. Thomas J. McHugh
  1. Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama, Japan 351-0198
  1. Correspondence should be addressed to Dr Thomas McHugh, RIKEN Brain Science Institute, Laboratory for Circuit and Behavioral Physiology, 2-1 Hirosawa, Wako-shi, Saitama, Japan. E-mail: tjmchugh{at}brain.riken.jp.
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Author contributions

  1. ↵2 Contributions: L.M.Y.Y. and T.J.M. designed research; L.M.Y.Y., M.E.W., and M.-C.C. performed research; L.M.Y.Y., D.P., and T.J.M. analyzed data; L.M.Y.Y., D.P., M.E.W., and T.J.M. wrote the paper.

Disclosures

  • ↵1 The authors report no conflict of interest.

  • ↵3 This work was supported by JSPS Kakenhi Young Scientist B no. 24700343 (L.M.Y.Y.) and the RIKEN Brain Science Institute (T.J.M.). We thank Arthur J. Y. Huang for technical support.

Funding

  • JSPS

    24700343
  • RIKEN Brain Science Institute

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CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations
Lily M. Y. Yu, Denis Polygalov, Marie E. Wintzer, Ming-Ching Chiang, Thomas J. McHugh
eNeuro 10 February 2016, 3 (1) ENEURO.0003-16.2016; DOI: 10.1523/ENEURO.0003-16.2016

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CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations
Lily M. Y. Yu, Denis Polygalov, Marie E. Wintzer, Ming-Ching Chiang, Thomas J. McHugh
eNeuro 10 February 2016, 3 (1) ENEURO.0003-16.2016; DOI: 10.1523/ENEURO.0003-16.2016
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Keywords

  • CA3
  • gamma
  • hippocampus
  • kainic acid
  • seizure
  • tetanus toxin

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