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Review, Sensory and Motor Systems

Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons

Ilya A. Rybak, Kimberly J. Dougherty and Natalia A. Shevtsova
eNeuro 8 September 2015, 2 (5) ENEURO.0069-15.2015; https://doi.org/10.1523/ENEURO.0069-15.2015
Ilya A. Rybak
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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Kimberly J. Dougherty
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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Natalia A. Shevtsova
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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eneuro: 2 (5)
eNeuro
Vol. 2, Issue 5
September/October 2015
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Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons
Ilya A. Rybak, Kimberly J. Dougherty, Natalia A. Shevtsova
eNeuro 8 September 2015, 2 (5) ENEURO.0069-15.2015; DOI: 10.1523/ENEURO.0069-15.2015

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Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons
Ilya A. Rybak, Kimberly J. Dougherty, Natalia A. Shevtsova
eNeuro 8 September 2015, 2 (5) ENEURO.0069-15.2015; DOI: 10.1523/ENEURO.0069-15.2015
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  • Article
    • Visual Overview
    • Abstract
    • Significance Statement
    • Introduction
    • Models of the locomotor CPG
    • Spinal interneurons identified from developmental and genetic studies
    • Spinal interneurons involved in locomotor rhythm generation: Shox2 cells
    • Ipsilaterally projecting, excitatory V2a interneurons
    • Flexor–extensor asymmetry in the organization of locomotor activity
    • Left–right coordination of activity in the spinal cord: frequency-dependent role of V0D and V0V CINs
    • Axon guidance and left–right coordination: role of Netrin-1, DCC, and EphA4
    • Flexor–extensor alternation: role of V1 and V2b interneurons
    • Conclusions
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
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Keywords

  • central pattern generator
  • computational modeling
  • flexor–extensor coordination
  • genetically identified neurons
  • left–right coordination
  • locomotion
  • spinal cord

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