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Research ArticleNew Research, Disorders of the Nervous System

Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury

Laura E. Villasana, Kristine N. Kim, Gary L. Westbrook and Eric Schnell
eNeuro 14 September 2015, 2 (5) ENEURO.0056-15.2015; https://doi.org/10.1523/ENEURO.0056-15.2015
Laura E. Villasana
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
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Kristine N. Kim
2VA Portland Health Care System, Portland, Oregon 97239
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Gary L. Westbrook
3The Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
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Eric Schnell
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
2VA Portland Health Care System, Portland, Oregon 97239
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0056-15.2015
PubMed 
26478908
Published By 
Society for Neuroscience
History 
  • Received May 21, 2015
  • Revision received July 24, 2015
  • Accepted July 31, 2015
  • Published online September 14, 2015.
Copyright & Usage 
Copyright 2015 © Villasana et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Laura E. Villasana1,
  2. Kristine N. Kim2,
  3. Gary L. Westbrook3 and
  4. Eric Schnell1,2
  1. 1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
  2. 2VA Portland Health Care System, Portland, Oregon 97239
  3. 3The Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
  1. Correspondence should be addressed to Dr. Eric Schnell, VA Portland Health Care System, 3710 SW US Veterans Hospital Road, P3ANES, Portland, OR 97239. E-mail: schneler{at}ohsu.edu.
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Author contributions

  1. Author Contributions: L.E.V., G.L.W., and E.S. designed research; L.E.V., K.N.K., and E.S. performed research; L.E.V. and E.S. analyzed data; L.E.V., G.L.W., and E.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was funded by a Department of Veterans Affairs Career Development Award (VA BLR&D CDA-2 005-10S; E.S.), a PVARF Summer Fellowship (K.N.K.), National Institutes of Health (NIH) Grant F32-NS083109 NRSA (L.E.V.), an Ellison Medical Foundation Award (G.L.W.), and NIH Grants R01-NS080979 (GLW) and P30-NS061800 (Oregon Health & Science University Imaging Center). We thank Drs. Zhi-Qi Xiong and Xuewen Cheng for providing Dcx-CreERT2 mice; and Dr. Stefanie Kaech-Petrie of the Oregon Health & Science University Advanced Light Microscopy Core for assistance with imaging.

Funding

  • Department of Veterans Affairs

    VA BLR&D CDA-2 005-10S
  • Portland VA Research Foundation

    Summer Fellowship
  • NIH

    F32-NS083109
  • NIH

    R01-NS080979
  • Ellison Medical Foundation

  • NIH

    P30-NS061800

Other Version

  • You are viewing the most recent version of this article.
  • previous version (September 14, 2015).
  • previous version (September 14, 2015).

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Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury
Laura E. Villasana, Kristine N. Kim, Gary L. Westbrook, Eric Schnell
eNeuro 14 September 2015, 2 (5) ENEURO.0056-15.2015; DOI: 10.1523/ENEURO.0056-15.2015

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Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury
Laura E. Villasana, Kristine N. Kim, Gary L. Westbrook, Eric Schnell
eNeuro 14 September 2015, 2 (5) ENEURO.0056-15.2015; DOI: 10.1523/ENEURO.0056-15.2015
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Keywords

  • adult neurogenesis
  • functional integration
  • hippocampus
  • maturation
  • synaptic integration
  • traumatic brain injury

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