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Research ArticleNew Research, Disorders of the Nervous System

Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32

Marina Polito, Elvire Guiot, Giuseppe Gangarossa, Sophie Longueville, Mohamed Doulazmi, Emmanuel Valjent, Denis Hervé, Jean-Antoine Girault, Danièle Paupardin-Tritsch, Liliana R. V. Castro and Pierre Vincent
eNeuro 25 August 2015, 2 (4) ENEURO.0060-15.2015; https://doi.org/10.1523/ENEURO.0060-15.2015
Marina Polito
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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Elvire Guiot
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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Giuseppe Gangarossa
3CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34094, France
4 Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, F-34094, France
5 Universités de Montpellier 1 & 2, UMR-5203, Montpellier, F-34094, France
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Sophie Longueville
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
6 Institut National de la Santé et de la Recherche Médicale UMR-S 839, Paris, France
7 Institut du Fer à Moulin, Paris, France
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Mohamed Doulazmi
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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Emmanuel Valjent
3CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34094, France
4 Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, F-34094, France
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Denis Hervé
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
6 Institut National de la Santé et de la Recherche Médicale UMR-S 839, Paris, France
7 Institut du Fer à Moulin, Paris, France
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Jean-Antoine Girault
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
6 Institut National de la Santé et de la Recherche Médicale UMR-S 839, Paris, France
7 Institut du Fer à Moulin, Paris, France
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Danièle Paupardin-Tritsch
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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  • ORCID record for Danièle Paupardin-Tritsch
Liliana R. V. Castro
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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Pierre Vincent
1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0060-15.2015
PubMed 
26465004
Published By 
Society for Neuroscience
History 
  • Received June 1, 2015
  • Revision received July 21, 2015
  • Accepted August 10, 2015
  • Published online August 25, 2015.
Copyright & Usage 
Copyright © 2015 Polito et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Marina Polito1,2,
  2. Elvire Guiot1,2,
  3. Giuseppe Gangarossa3,4,5,
  4. Sophie Longueville2,6,7,
  5. Mohamed Doulazmi1,2,
  6. Emmanuel Valjent3,4,
  7. Denis Hervé2,6,7,
  8. Jean-Antoine Girault2,6,7,
  9. Danièle Paupardin-Tritsch1,2,
  10. Liliana R. V. Castro1,2 and
  11. Pierre Vincent1,2
  1. 1CNRS, UMR8256 “Biological Adaptation and Ageing”, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
  2. 2Université Pierre et Marie Curie (UPMC, Paris 6), Sorbonne Universités, Paris, F-75005, France
  3. 3CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34094, France
  4. 4 Institut National de la Santé et de la Recherche Médicale, U661, Montpellier, F-34094, France
  5. 5 Universités de Montpellier 1 & 2, UMR-5203, Montpellier, F-34094, France
  6. 6 Institut National de la Santé et de la Recherche Médicale UMR-S 839, Paris, France
  7. 7 Institut du Fer à Moulin, Paris, France
  1. Correspondence should be addressed to Pierre Vincent, UMR8256, 9, quai St. Bernard, F-75005 PARIS, France. E-mail: pierre.vincent{at}upmc.fr.
View Full Text

Author contributions

  1. ↵2 Author contributions: M.P., E.V., D.H., D.P.-T., L.R.V.C., and P.V. designed research. M.P., E.G., G.G., S.L., and L.R.V.C. performed research. M.P., E.G., G.G., S.L., M.D., L.R.V.C., and P.V. analyzed data. E.V., D.H., J.A.-G., D.P.-T., L.R.V.C., and P.V. wrote the paper.

View Abstract

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work was supported by grants from ATIP-Avenir (Inserm) and from the Agence Nationale de la Recherche, ANR-2010-JCJC-1412) to EV and ANR09-MNPS-014 to DH, and ERC to JAG. The groups of PV, and JAG and DH are part of the Bio-Psy Laboratory of Excellence.

Funding

  • Atip-Avenir

  • Agence Nationale de la Recherche

    ANR-2010-JCJC-1412
  • Agence Nationale de la Recherche

    ANR09-MNPS-014
  • ERC

  • Bio-Psy

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  • You are viewing the most recent version of this article.
  • previous version (August 25, 2015).

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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32
Marina Polito, Elvire Guiot, Giuseppe Gangarossa, Sophie Longueville, Mohamed Doulazmi, Emmanuel Valjent, Denis Hervé, Jean-Antoine Girault, Danièle Paupardin-Tritsch, Liliana R. V. Castro, Pierre Vincent
eNeuro 25 August 2015, 2 (4) ENEURO.0060-15.2015; DOI: 10.1523/ENEURO.0060-15.2015

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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32
Marina Polito, Elvire Guiot, Giuseppe Gangarossa, Sophie Longueville, Mohamed Doulazmi, Emmanuel Valjent, Denis Hervé, Jean-Antoine Girault, Danièle Paupardin-Tritsch, Liliana R. V. Castro, Pierre Vincent
eNeuro 25 August 2015, 2 (4) ENEURO.0060-15.2015; DOI: 10.1523/ENEURO.0060-15.2015
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Keywords

  • biosensor imaging
  • cAMP
  • phosphodiesterase
  • protein kinase
  • schizophrenia
  • striatum

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