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Research ArticleNew Research, Neuronal Excitability

Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3

Kaoutsar Nasrallah, Rebecca A. Piskorowski and Vivien Chevaleyre
eNeuro 15 July 2015, 2 (4) ENEURO.0049-15.2015; DOI: https://doi.org/10.1523/ENEURO.0049-15.2015
Kaoutsar Nasrallah
Team Synaptic Plasticity and Neural Networks, FR3636, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8118, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
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Rebecca A. Piskorowski
Team Synaptic Plasticity and Neural Networks, FR3636, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8118, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
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Vivien Chevaleyre
Team Synaptic Plasticity and Neural Networks, FR3636, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8118, Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
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This article has a correction. Please see:

  • Correction: Nasrallah et al., Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3 (eNeuro July/August 2015, 2(4) e0049-15.2015 1-12 http://dx.doi.org/10.1523/ENEURO.0049-15.2015) - March 08, 2016

Abstract

Area CA2 is emerging as an important region for hippocampal memory formation. However, how CA2 pyramidal neurons (PNs) are engaged by intrahippocampal inputs remains unclear. Excitatory transmission between CA3 and CA2 is strongly inhibited and is not plastic. We show in mice that different patterns of activity can in fact increase the excitatory drive between CA3 and CA2. We provide evidence that this effect is mediated by a long-term depression at inhibitory synapses (iLTD), as it is evoked by the same protocols and shares the same pharmacology. In addition, we show that the net excitatory drive of distal inputs is also increased after iLTD induction. The disinhibitory increase in excitatory drive is sufficient to allow CA3 inputs to evoke action potential firing in CA2 PNs. Thus, these data reveal that the output of CA2 PNs can be gated by the unique activity-dependent plasticity of inhibitory neurons in area CA2.

  • area CA2
  • δ opioid receptor
  • disinhibition
  • hippocampus
  • interneuron
  • long-term depression

Footnotes

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This research has been supported by ATIP-Avenir and the Agence Nationale de la Recherche (Grants ANR-12-BSV4-0021-01 and ANR-13-JSV4-0002), and the Ville de Paris program Emergence.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3
Kaoutsar Nasrallah, Rebecca A. Piskorowski, Vivien Chevaleyre
eNeuro 15 July 2015, 2 (4) ENEURO.0049-15.2015; DOI: 10.1523/ENEURO.0049-15.2015

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Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3
Kaoutsar Nasrallah, Rebecca A. Piskorowski, Vivien Chevaleyre
eNeuro 15 July 2015, 2 (4) ENEURO.0049-15.2015; DOI: 10.1523/ENEURO.0049-15.2015
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Keywords

  • area CA2
  • δ opioid receptor
  • disinhibition
  • hippocampus
  • interneuron
  • long-term depression

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