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Research ArticleNew Research, Neuronal Excitability

Mechanisms Leading to Rhythm Cessation in the Respiratory PreBötzinger Complex Due to Piecewise Cumulative Neuronal Deletions

Hanbing Song, John A. Hayes, Nikolas C. Vann, M. Drew LaMar and Christopher A. Del Negro
eNeuro 18 August 2015, 2 (4) ENEURO.0031-15.2015; https://doi.org/10.1523/ENEURO.0031-15.2015
Hanbing Song
1Department of Applied Science, The College of William & Mary, Williamsburg, Virginia 23187-8795
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John A. Hayes
1Department of Applied Science, The College of William & Mary, Williamsburg, Virginia 23187-8795
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Nikolas C. Vann
1Department of Applied Science, The College of William & Mary, Williamsburg, Virginia 23187-8795
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M. Drew LaMar
2Department of Biology, The College of William & Mary, Williamsburg, Virginia 23187-8795
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Christopher A. Del Negro
1Department of Applied Science, The College of William & Mary, Williamsburg, Virginia 23187-8795
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0031-15.2015
PubMed 
26465010
Published By 
Society for Neuroscience
History 
  • Received April 10, 2015
  • Revision received August 13, 2015
  • Accepted August 14, 2015
  • Published online August 18, 2015.
Copyright & Usage 
Copyright © 2015 Song et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hanbing Song1,
  2. John A. Hayes1,
  3. Nikolas C. Vann1,
  4. M. Drew LaMar2,* and
  5. Christopher A. Del Negro1,*
  1. 1Department of Applied Science, The College of William & Mary, Williamsburg, Virginia 23187-8795
  2. 2Department of Biology, The College of William & Mary, Williamsburg, Virginia 23187-8795
  1. Correspondence should be addressed to Dr Christopher A. Del Negro, Department of Applied Science, The College of William & Mary, Williamsburg, VA 23187-8795. E-mail: cadeln{at}wm.edu.
View Full Text

Author contributions

  1. ↵2 Author contributions: H.S. performed the research and simulations, performed all the analyses; J.A.H. provided technical advice regarding simulation and software design; N.C.V. provided technical advice regarding experimental design and simulations; M.D.L. performed the research and simulations, closely advised H.S. and C.A.D.N. regarding mathematics; J.A.H. and M.D.L. interpreted data; M.D.L. and C.A.D.N. analyzed data; C.A.D.N. supervised the project, helped design and perform the research; H.S., M.D.L., and C.A.D.N. wrote the paper.

  2. ↵* M.D.L. and C.A.D.N. contributed equally to this work.

View Abstract

Disclosures

  • ↵1 The authors declare no conflicts of interest.

  • ↵3 This work was supported by NIH Grant HL104127 (PI; C.A.D.N.).

Funding

  • NHLBI

    HL104127

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eneuro: 2 (4)
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Mechanisms Leading to Rhythm Cessation in the Respiratory PreBötzinger Complex Due to Piecewise Cumulative Neuronal Deletions
Hanbing Song, John A. Hayes, Nikolas C. Vann, M. Drew LaMar, Christopher A. Del Negro
eNeuro 18 August 2015, 2 (4) ENEURO.0031-15.2015; DOI: 10.1523/ENEURO.0031-15.2015

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Mechanisms Leading to Rhythm Cessation in the Respiratory PreBötzinger Complex Due to Piecewise Cumulative Neuronal Deletions
Hanbing Song, John A. Hayes, Nikolas C. Vann, M. Drew LaMar, Christopher A. Del Negro
eNeuro 18 August 2015, 2 (4) ENEURO.0031-15.2015; DOI: 10.1523/ENEURO.0031-15.2015
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Keywords

  • cumulative ablation
  • Dbx1
  • network
  • recurrent excitation
  • rhythmogenesis
  • synaptic transmission

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