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Research ArticleNew Research, Development

Synergistic Effects of Age on Patterns of White and Gray Matter Volume across Childhood and Adolescence

Signe Bray, Mark Krongold, Cassandra Cooper and Catherine Lebel
eNeuro 1 July 2015, 2 (4) ENEURO.0003-15.2015; https://doi.org/10.1523/ENEURO.0003-15.2015
Signe Bray
1Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
2Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
3Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, Alberta, Canada T3B 6A8
4Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada T3B 6A8
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Mark Krongold
3Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, Alberta, Canada T3B 6A8
4Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada T3B 6A8
5Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada T2N 1N4
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Cassandra Cooper
3Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, Alberta, Canada T3B 6A8
4Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada T3B 6A8
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Catherine Lebel
1Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
2Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
3Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, Alberta, Canada T3B 6A8
4Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada T3B 6A8
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0003-15.2015
PubMed 
26464999
Published By 
Society for Neuroscience
History 
  • Received January 11, 2015
  • Revision received March 25, 2015
  • Accepted April 30, 2015
  • Published online July 1, 2015.
Copyright & Usage 
Copyright © 2015 Bray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Signe Bray1,2,3,4,
  2. Mark Krongold3,4,5,
  3. Cassandra Cooper3,4 and
  4. Catherine Lebel1,2,3,4
  1. 1Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
  2. 2Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 1N4
  3. 3Child and Adolescent Imaging Research Program, Alberta Children's Hospital, Calgary, Alberta, Canada T3B 6A8
  4. 4Alberta Children’s Hospital Research Institute, Calgary, Alberta, Canada T3B 6A8
  5. 5Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada T2N 1N4
  1. Correspondence should be addressed to Signe Bray, Alberta Children’s Hospital, 2888 Shaganappi Trail NW, A0-401, Calgary, Alberta, T3B 6A8, Canada. E-mail: slbray{at}ucalgary.ca.
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Author contributions

  1. ↵2 Author Contributions: S.B. designed research, analyzed data and wrote the paper; M.K. and C.C. analyzed data and wrote the paper; C.L. analyzed data and wrote the paper.

View Abstract

Disclosures

  • ↵1 C.L.’s spouse is an employee of General Electric Healthcare.

  • ↵3 M.K. was supported by an NSERC CGS-M and C.C. was supported by an NSERC USRA. This work was supported by an NSERC Discovery Grant (S.B.), and the Alberta Children’s Hospital Foundation. Data used in the preparation of this article were obtained from the Pediatric MRI Data Repository created by the NIH MRI Study of Normal Brain Development. This is a multisite, longitudinal study of typically developing children, from ages newborn through young adulthood, conducted by the Brain Development Cooperative Group and supported by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke (N01-HD02-3343; N01-MH9-0002; and N01-NS-9-2314, N01-NS-9-2315, N01-NS-9-2316, N01-NS-9-2317, N01-NS-9-2319, and N01-NS-9-2320). A listing of the participating sites and a complete listing of the study investigators can be found at http://www.bic.mni.mcgill.ca/nihpd/info/participating_centers.html. We thank the families who gave their time to participate in this study and the Brain Development Cooperative Group for making these data available.

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)

    501100000038; DG
  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)

    501100000038; CGS-M
  • Alberta Children's Hospital Foundation

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)

    501100000038; USRA

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Total 20263959725
Total704101931460
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Synergistic Effects of Age on Patterns of White and Gray Matter Volume across Childhood and Adolescence
Signe Bray, Mark Krongold, Cassandra Cooper, Catherine Lebel
eNeuro 1 July 2015, 2 (4) ENEURO.0003-15.2015; DOI: 10.1523/ENEURO.0003-15.2015

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Synergistic Effects of Age on Patterns of White and Gray Matter Volume across Childhood and Adolescence
Signe Bray, Mark Krongold, Cassandra Cooper, Catherine Lebel
eNeuro 1 July 2015, 2 (4) ENEURO.0003-15.2015; DOI: 10.1523/ENEURO.0003-15.2015
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Keywords

  • cortex
  • MRI
  • structural covariance network
  • white matter

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