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Research ArticleNew Research, Disorders of the Nervous System

Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1G93A Rat Model

Gretchen M. Thomsen, Jean-Philippe Vit, Alexander Lamb, Genevieve Gowing, Oksana Shelest, Mor Alkaslasi, Eric J. Ley and Clive N. Svendsen
eNeuro 22 June 2015, 2 (3) ENEURO.0059-14.2015; https://doi.org/10.1523/ENEURO.0059-14.2015
Gretchen M. Thomsen
1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Jean-Philippe Vit
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048
3 Biobehavioral Research Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Alexander Lamb
4Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Genevieve Gowing
1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Oksana Shelest
1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Mor Alkaslasi
1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Eric J. Ley
4Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Clive N. Svendsen
1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0059-14.2015
PubMed 
26464984
Published By 
Society for Neuroscience
History 
  • Received November 12, 2014
  • Revision received May 17, 2015
  • Accepted May 21, 2015
  • Published online June 22, 2015.
Copyright & Usage 
Copyright © 2015 Thomsen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Gretchen M. Thomsen1,
  2. Jean-Philippe Vit2,3,
  3. Alexander Lamb4,
  4. Genevieve Gowing1,
  5. Oksana Shelest1,
  6. Mor Alkaslasi1,
  7. Eric J. Ley4 and
  8. Clive N. Svendsen1,2
  1. 1 Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048
  2. 2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048
  3. 3 Biobehavioral Research Core, Cedars-Sinai Medical Center, Los Angeles, CA 90048
  4. 4Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048
  1. Correspondence should be addressed to either of the following: Clive Svendsen at the above address. E-mail: Clive.Svendsen{at}cshs.org; or Eric Ley at the above address. E-mail: Eric.Ley{at}cshs.org.
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Author contributions

  1. ↵2 Author Contributions: G.M.T., A.L., G.G., E.J.L., C.N.S. designed experiments; G.M.T., J.P.V., A.L., R.E., M.A. performed research; G.M.T. analyzed data; G.M.T., E.J.L., C.N.S. wrote the paper.

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Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work was supported by the Board of Governors Regenerative Medicine Institute and the ALS Association.

Funding

  • ALS Association

  • Board of Governors Regenerative Medicine Institute

Other Version

  • You are viewing the most recent version of this article.
  • previous version (June 22, 2015).

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May/June 2015
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Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1G93A Rat Model
Gretchen M. Thomsen, Jean-Philippe Vit, Alexander Lamb, Genevieve Gowing, Oksana Shelest, Mor Alkaslasi, Eric J. Ley, Clive N. Svendsen
eNeuro 22 June 2015, 2 (3) ENEURO.0059-14.2015; DOI: 10.1523/ENEURO.0059-14.2015

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Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1G93A Rat Model
Gretchen M. Thomsen, Jean-Philippe Vit, Alexander Lamb, Genevieve Gowing, Oksana Shelest, Mor Alkaslasi, Eric J. Ley, Clive N. Svendsen
eNeuro 22 June 2015, 2 (3) ENEURO.0059-14.2015; DOI: 10.1523/ENEURO.0059-14.2015
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Keywords

  • ALS
  • amyotrophic lateral sclerosis
  • neurodegeneration
  • SOD1
  • TBI
  • traumatic brain injury

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