Research ArticleNew Research, Disorders of the Nervous System
Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I
Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne and John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; https://doi.org/10.1523/ENEURO.0016-14.2015
Laleh Sinai
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Ontario, M5S 3E1, Canada
Evgueni A. Ivakine
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
Emily Lam
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Marielle Deurloo
4Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8
Joana Dida
5Department of Psychology, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, M5S 3G3, Canada
Ralph A. Zirngibl
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Cynthia Jung
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
Jane E. Aubin
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Zhong-Ping Feng
4Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8
John Yeomans
5Department of Psychology, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, M5S 3G3, Canada
McInnes Roderick R.
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
7Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2, Canada
Lucy R. Osborne
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
8Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
John C. Roder
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Ontario, M5S 3E1, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I
Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne, John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; DOI: 10.1523/ENEURO.0016-14.2015
Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I
Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne, John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; DOI: 10.1523/ENEURO.0016-14.2015
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- Article
- Abstract
- Significance Statement
- Introduction
- Materials and Methods
- Results
- Exploratory activity and anxiety
- Sensory and motor function
- Acoustic startle response
- Learning, memory, and attention deficits
- Cellular localization of TFII-I and TRPC3
- Discussion
- Acknowledgments
- Footnotes
- REFERENCES
- Synthesis
- Author Response
- Figures & Data
- Info & Metrics
- eLetters
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