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Research ArticleNew Research, Disorders of the Nervous System

Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I

Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne and John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; DOI: https://doi.org/10.1523/ENEURO.0016-14.2015
Laleh Sinai
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Ontario, M5S 3E1, Canada
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Evgueni A. Ivakine
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
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Emily Lam
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Marielle Deurloo
4Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8
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Joana Dida
5Department of Psychology, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, M5S 3G3, Canada
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Ralph A. Zirngibl
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Cynthia Jung
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
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Jane E. Aubin
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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  • ORCID record for Jane E. Aubin
Zhong-Ping Feng
4Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8
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John Yeomans
5Department of Psychology, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, M5S 3G3, Canada
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McInnes Roderick R.
3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
7Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2, Canada
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Lucy R. Osborne
1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
8Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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John C. Roder
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Ontario, M5S 3E1, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0016-14.2015
PubMed 
26464974
Published By 
Society for Neuroscience
History 
  • Received September 4, 2014
  • Revision received March 2, 2015
  • Accepted March 2, 2015
  • Published online March 6, 2015.
Copyright & Usage 
Copyright © 2015 Sinal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Laleh Sinai1,2,
  2. Evgueni A. Ivakine3,
  3. Emily Lam1,
  4. Marielle Deurloo4,
  5. Joana Dida5,
  6. Ralph A. Zirngibl6,
  7. Cynthia Jung3,
  8. Jane E. Aubin6,
  9. Zhong-Ping Feng4,
  10. John Yeomans5,
  11. McInnes Roderick R.3,6,7,
  12. Lucy R. Osborne1,6,8 and
  13. John C. Roder2,6
  1. 1Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
  2. 2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto Ontario, M5S 3E1, Canada
  3. 3Programs in Genomics and Developmental Biology, The Hospital for Sick Children Research Institute, Peter Gilgan Center for Research and Learning, Toronto, Ontario, M5G 0A4, Canada
  4. 4Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8
  5. 5Department of Psychology, Center for Biological Timing and Cognition, University of Toronto, Toronto, Ontario, M5S 3G3, Canada
  6. 6Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
  7. 7Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, H3T 1E2, Canada
  8. 8Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
  1. Correspondence should be addressed to either of the following: Lucy R. Osborne, Departments of Medicine and Molecular Genetics, 7360, Medical Sciences Building, 1 King’s College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada, E-mail: lucy.osborne{at}utoronto.ca; or Laleh Sinai, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto ON, M5S 3E1, Canada, E-mail: sinai.laleh{at}gmail.com.
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Author contributions

  1. ↵1 Author contributions: L.S., M.D., J.E.A., Z.-P.F., J.Y., R.R.M., L.R.O., and J.C.R. designed research; L.S., E.A.I., E.L., M.D., J.D., R.A.Z., and C.J. performed research; L.S., E.L., M.D., J.D., R.A.Z., J.E.A., Z.-P.F., J.Y., L.R.O., and J.C.R. analyzed data; L.S. and L.R.O. wrote the paper.

View Abstract

Disclosures

  • ↵2 This work was supported in part by grants from the Canadian Institutes of Health Research to J.E.A. (FRN69198) and L.R.O. (MOP77720).

Funding

  • Canadian Institutes of Health Research

    MOP77720
  • Canadian Institutes of Health Research

    FRN69198

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Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I
Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne, John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; DOI: 10.1523/ENEURO.0016-14.2015

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Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I
Laleh Sinai, Evgueni A. Ivakine, Emily Lam, Marielle Deurloo, Joana Dida, Ralph A. Zirngibl, Cynthia Jung, Jane E. Aubin, Zhong-Ping Feng, John Yeomans, McInnes Roderick R., Lucy R. Osborne, John C. Roder
eNeuro 6 March 2015, 2 (2) ENEURO.0016-14.2015; DOI: 10.1523/ENEURO.0016-14.2015
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  • Article
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    • Significance Statement
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    • Exploratory activity and anxiety
    • Sensory and motor function
    • Acoustic startle response
    • Learning, memory, and attention deficits
    • Cellular localization of TFII-I and TRPC3
    • Discussion
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Keywords

  • calcium channel
  • General transcription factor 2 I
  • mouse behavior
  • Src tyrosine kinase
  • Williams-Beuren syndrome

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