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Research ArticleNegative Results, Disorders of the Nervous System

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice

David N. Hauser, Christopher T. Primiani, Rebekah G. Langston, Ravindran Kumaran and Mark R. Cookson
eNeuro 24 February 2015, 2 (1) ENEURO.0075-14.2015; https://doi.org/10.1523/ENEURO.0075-14.2015
David N. Hauser
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
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Christopher T. Primiani
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
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Rebekah G. Langston
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
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Ravindran Kumaran
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
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Mark R. Cookson
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0075-14.2015
PubMed 
26464968
Published By 
Society for Neuroscience
History 
  • Received December 22, 2014
  • Revision received February 13, 2015
  • Accepted February 13, 2015
  • Published online February 24, 2015.
Copyright & Usage 
Copyright © 2015 Hauser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. David N. Hauser,
  2. Christopher T. Primiani,
  3. Rebekah G. Langston,
  4. Ravindran Kumaran and
  5. Mark R. Cookson
  1. Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
  1. Correspondence should be addressed to Dr. Mark R. Cookson, Cell Biology and Gene Expression Section, NIA, Building 35, Room 1A116, 35 Convent Drive, MSC 3707, Bethesda, MD 20892-3707. E-mail: Cookson{at}mail.nih.gov.
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Author contributions

  1. ↵2 D.N.H. and M.R.C. designed research; D.N.H., C.T.P., and R.K. performed research; D.N.H., C.T.P., R.G.L., and M.R.C. analyzed data; D.N.H., C.T.P., and M.R.C. wrote the paper.

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Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work was supported entirely by the Intramural Research Program of the NIH, National Institute on Aging.

Funding

  • Intramural Research Program of the NIH, National Institute on Aging

    AG000953

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The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice
David N. Hauser, Christopher T. Primiani, Rebekah G. Langston, Ravindran Kumaran, Mark R. Cookson
eNeuro 24 February 2015, 2 (1) ENEURO.0075-14.2015; DOI: 10.1523/ENEURO.0075-14.2015

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The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice
David N. Hauser, Christopher T. Primiani, Rebekah G. Langston, Ravindran Kumaran, Mark R. Cookson
eNeuro 24 February 2015, 2 (1) ENEURO.0075-14.2015; DOI: 10.1523/ENEURO.0075-14.2015
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Keywords

  • DJ-1
  • mtDNA
  • Neurodegeration
  • Parkinsonism
  • Polg mutator
  • substantia nigra

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