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Research ArticleNew Research, Disorders of the Nervous System

Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease

Sandra M. Holley, Prasad R. Joshi, Anna Parievsky, Laurie Galvan, Jane Y. Chen, Yvette E. Fisher, My N. Huynh, Carlos Cepeda and Michael S. Levine
eNeuro 24 February 2015, 2 (1) ENEURO.0008-14.2015; https://doi.org/10.1523/ENEURO.0008-14.2015
Sandra M. Holley
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Prasad R. Joshi
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Anna Parievsky
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Laurie Galvan
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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  • ORCID record for Laurie Galvan
Jane Y. Chen
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Yvette E. Fisher
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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My N. Huynh
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Carlos Cepeda
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Michael S. Levine
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0008-14.2015
PubMed 
26203463
Published By 
Society for Neuroscience
History 
  • Received August 27, 2014
  • Revision received February 17, 2015
  • Accepted February 20, 2015
  • Published online February 24, 2015.
Copyright & Usage 
Copyright © 2015 Holley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sandra M. Holley*,
  2. Prasad R. Joshi*,
  3. Anna Parievsky,
  4. Laurie Galvan,
  5. Jane Y. Chen,
  6. Yvette E. Fisher,
  7. My N. Huynh,
  8. Carlos Cepeda and
  9. Michael S. Levine
  1. Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095
  1. Correspondence should be addressed to Dr. Michael S. Levine, IDDRC, Semel Institute for Neuroscience, Room 58-258, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095. E-mail: mlevine{at}mednet.ucla.edu.
View Full Text

Author contributions

  1. ↵2 Author Contributions: S.M.H., P.J., A.P., L.G., J.Y.C., Y.E.F., and M.H. performed research; S.M.H., P.J., A.P., L.G., J.Y.C., Y.E.F., M.H., C.C., and M.S.L. analyzed data; S.M.H., P.J., C.C., and M.S.L. wrote the paper; C.C. and M.S.L. designed research.

  2. ↵* S.M.H. and P.R.J. contributed equally to this work.

View Abstract

Disclosures

  • ↵1 The authors report no financial conflicts of interest.

  • ↵3 This work was supported by Cure HD Initiative, Inc. and USPHS Grant NS41574.

Funding

  • NIH

    NS41574
  • Cure Huntington's Disease Initiative (CHDI Foundation)

    100006500

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  • You are viewing the most recent version of this article.
  • previous version (February 24, 2015).

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Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease
Sandra M. Holley, Prasad R. Joshi, Anna Parievsky, Laurie Galvan, Jane Y. Chen, Yvette E. Fisher, My N. Huynh, Carlos Cepeda, Michael S. Levine
eNeuro 24 February 2015, 2 (1) ENEURO.0008-14.2015; DOI: 10.1523/ENEURO.0008-14.2015

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Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington’s Disease
Sandra M. Holley, Prasad R. Joshi, Anna Parievsky, Laurie Galvan, Jane Y. Chen, Yvette E. Fisher, My N. Huynh, Carlos Cepeda, Michael S. Levine
eNeuro 24 February 2015, 2 (1) ENEURO.0008-14.2015; DOI: 10.1523/ENEURO.0008-14.2015
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Keywords

  • cholinergic interneurons
  • GABA
  • Huntington’s disease
  • optogenetics
  • R6/2 mouse model
  • striatum

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