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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Numbers of Granule Cells and GABAergic Boutons Are Correlated in Shrunken Sclerotic Hippocampi of Sea Lions with Temporal Lobe Epilepsy

Megan Wyeth, David D. R. Krucik, Chloé J. Thorbrogger, Cara Field and Paul S. Buckmaster
eNeuro 9 March 2026, 13 (3) ENEURO.0389-25.2026; https://doi.org/10.1523/ENEURO.0389-25.2026
Megan Wyeth
1Department of Comparative Medicine, Stanford University, Palo Alto, California 94304
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David D. R. Krucik
1Department of Comparative Medicine, Stanford University, Palo Alto, California 94304
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Chloé J. Thorbrogger
1Department of Comparative Medicine, Stanford University, Palo Alto, California 94304
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Cara Field
2The Marine Mammal Center, Sausalito, California 94965
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Paul S. Buckmaster
1Department of Comparative Medicine, Stanford University, Palo Alto, California 94304
3Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California 94304
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0389-25.2026
PubMed 
41802862
Published By 
Society for Neuroscience
History 
  • Received October 21, 2025
  • Revision received February 25, 2026
  • Accepted March 2, 2026
  • Published online March 9, 2026.
Copyright & Usage 
Copyright © 2026 Wyeth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Megan Wyeth1,
  2. David D. R. Krucik1,
  3. Chloé J. Thorbrogger1,
  4. Cara Field2 and
  5. Paul S. Buckmaster1,3
  1. 1Department of Comparative Medicine, Stanford University, Palo Alto, California 94304
  2. 2The Marine Mammal Center, Sausalito, California 94965
  3. 3Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California 94304
  1. Correspondence should be addressed to Megan Wyeth at mwyeth{at}stanford.edu.
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Author contributions

  1. Author contributions: M.W. and P.S.B. designed research; M.W., D.D.R.K., C.J.T., C.F., and P.S.B. performed research; M.W. and P.S.B. analyzed data; M.W. and P.S.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Science Foundation (OCE-131821), National Institute of Environmental Health Sciences (ES021960), National Institute of Neurological Disorders and Stroke (NS107290, NS136433), and National Institutes of Health Office of the Director (OD010989, OD011121). Animals were sampled under the Marine Mammal Protection Act permit number 18786. The data that support the findings of this study are openly available in Dryad at http://doi.org/10.5061/dryad.t4b8gtjd5.

Funding

  • National Science Foundation (NSF)

    OCE-131821
  • HHS | NIH | National Institute of Environmental Health Sciences (DEHS)

    ES021960
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS107290; NS136433
  • HHS | NIH | NIH Office of the Director (OD)

    OD010989; OD011121

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eneuro: 13 (3)
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March 2026
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Numbers of Granule Cells and GABAergic Boutons Are Correlated in Shrunken Sclerotic Hippocampi of Sea Lions with Temporal Lobe Epilepsy
Megan Wyeth, David D. R. Krucik, Chloé J. Thorbrogger, Cara Field, Paul S. Buckmaster
eNeuro 9 March 2026, 13 (3) ENEURO.0389-25.2026; DOI: 10.1523/ENEURO.0389-25.2026

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Numbers of Granule Cells and GABAergic Boutons Are Correlated in Shrunken Sclerotic Hippocampi of Sea Lions with Temporal Lobe Epilepsy
Megan Wyeth, David D. R. Krucik, Chloé J. Thorbrogger, Cara Field, Paul S. Buckmaster
eNeuro 9 March 2026, 13 (3) ENEURO.0389-25.2026; DOI: 10.1523/ENEURO.0389-25.2026
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Keywords

  • dentate gyrus
  • GABAergic
  • granule cell
  • interneuron
  • stereology
  • terminal

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