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Research ArticleResearch Article: New Research, Cognition and Behavior

Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens

Samantha K. Saland, Florian Duclot, Mary K. Lobo and Mohamed Kabbaj
eNeuro 17 December 2025, 13 (1) ENEURO.0419-25.2025; https://doi.org/10.1523/ENEURO.0419-25.2025
Samantha K. Saland
1Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306
2Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, Florida 32306
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Florian Duclot
1Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306
2Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, Florida 32306
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Mary K. Lobo
3Department of Neurobiology, School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland 21201
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Mohamed Kabbaj
1Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306
2Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, Florida 32306
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0419-25.2025
PubMed 
41407537
Published By 
Society for Neuroscience
History 
  • Received November 13, 2025
  • Accepted November 25, 2025
  • Published online December 17, 2025.
Copyright & Usage 
Copyright © 2026 Saland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Samantha K. Saland1,2,*,
  2. Florian Duclot1,2,*,
  3. Mary K. Lobo3 and
  4. Mohamed Kabbaj1,2
  1. 1Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306
  2. 2Program in Neuroscience, College of Medicine, Florida State University, Tallahassee, Florida 32306
  3. 3Department of Neurobiology, School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland 21201
  1. Correspondence should be addressed to Samantha K. Saland at samantha.saland-duclot{at}med.fsu.edu or Mohamed Kabbaj at mohamed.kabbaj{at}med.fsu.edu.
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Author contributions

  1. Author contributions: S.K.S. and M.K. designed research; S.K.S. and F.D. performed research; S.K.S., F.D., M.K.L., and M.K. analyzed data; S.K.S., F.D., M.K.L., and M.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests

  • This work was supported by the National Institute of Health Grant R01DA043461 to M.K. We thank Dr. Amber Brown from the FSU NGS Library Facility for the preparation of libraries, as well as Dr. Roger Mercer, Dr. Cynthia Vied, and Dr. Yanming Yang from the FSU Translational Science Laboratory for the generation and demultiplexing of sequencing data.

  • ↵*S.K.S. and F.D. contributed equally to this work.

Funding

  • HHS | NIH | National Institute of Mental Health (NIMH)

    R01DA043461

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Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens
Samantha K. Saland, Florian Duclot, Mary K. Lobo, Mohamed Kabbaj
eNeuro 17 December 2025, 13 (1) ENEURO.0419-25.2025; DOI: 10.1523/ENEURO.0419-25.2025

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Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens
Samantha K. Saland, Florian Duclot, Mary K. Lobo, Mohamed Kabbaj
eNeuro 17 December 2025, 13 (1) ENEURO.0419-25.2025; DOI: 10.1523/ENEURO.0419-25.2025
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Keywords

  • estrous cycle
  • ketamine
  • medium spiny neurons
  • nucleus accumbens
  • sensitization
  • translatome

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