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Research ArticleResearch Article: Negative Results, Development

Partial Deletion of Cxcl12 from Hippocampal Cajal–Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors

Rebekah van Bruggen, Karla Manzanet Freyre, Sangeetha Vasanthkumar, Mi Wang and Qiumin Tan
eNeuro 14 January 2026, 13 (1) ENEURO.0245-25.2025; https://doi.org/10.1523/ENEURO.0245-25.2025
Rebekah van Bruggen
1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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Karla Manzanet Freyre
1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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Sangeetha Vasanthkumar
1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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Mi Wang
1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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Qiumin Tan
1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
2Women and Children’s Health Research Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0245-25.2025
PubMed 
41535131
Published By 
Society for Neuroscience
History 
  • Received June 18, 2025
  • Revision received December 4, 2025
  • Accepted December 16, 2025
  • Published online January 14, 2026.
Copyright & Usage 
Copyright © 2026 van Bruggen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Rebekah van Bruggen1,*,
  2. Karla Manzanet Freyre1,*,
  3. Sangeetha Vasanthkumar1,*,
  4. Mi Wang1,* and
  5. Qiumin Tan1,2
  1. 1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
  2. 2Women and Children’s Health Research Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
  1. Correspondence should be addressed to Qiumin Tan at qiumin{at}ualberta.ca.
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Author contributions

  1. Author contributions: Q.T. designed research; R.v.B., K.M.F., S.V., and M.W. performed research; R.v.B., K.M.F., S.V., and M.W. analyzed data; R.v.B., K.M.F., S.V., M.W., and Q.T. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Dr. Alessandra Pierani (Université de Paris, Paris, France) for the generous gift of the ΔNp73-Cre transgenic mouse line. We also thank Dr. Sarah Hughes (University of Alberta) for her assistance with confocal microscopy. Qiumin Tan receives support from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2019-06153), the Canada Foundation for Innovation (Award 38985), and the Canadian Institutes of Health Research (MRC-177440 and PJT-178103). This study has been funded by the generosity of the Stollery Children's Hospital Foundation and the Alberta Women's Health Foundation through the Women and Children's Health Research Institute. Qiumin Tan is a Tier 2 Canada Research Chair in Neurodevelopmental Disorders. This study was undertaken, in part, thanks to funding from the Canada Research Chairs program.

  • ↵*R.v.B., K.M.F., S.V., and M.W. contributed equally to this work.

Funding

  • Natural Sciences and Engineering Research Council of Canada (NSERC)

    RGPIN‐2019‐06153
  • Canada Foundation for Innovation (CFI)

    Award 38985
  • Canadian Institutes of Health Research (CIHR)

    MRC‐177440; PJT‐178103
  • Women and Children's Health Research Institute (WCHRI)

  • Canada Research Chairs (CRC)

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eneuro: 13 (1)
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Partial Deletion of Cxcl12 from Hippocampal Cajal–Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors
Rebekah van Bruggen, Karla Manzanet Freyre, Sangeetha Vasanthkumar, Mi Wang, Qiumin Tan
eNeuro 14 January 2026, 13 (1) ENEURO.0245-25.2025; DOI: 10.1523/ENEURO.0245-25.2025

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Partial Deletion of Cxcl12 from Hippocampal Cajal–Retzius Cells Does Not Disrupt Dentate Gyrus Development or Neurobehaviors
Rebekah van Bruggen, Karla Manzanet Freyre, Sangeetha Vasanthkumar, Mi Wang, Qiumin Tan
eNeuro 14 January 2026, 13 (1) ENEURO.0245-25.2025; DOI: 10.1523/ENEURO.0245-25.2025
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Keywords

  • behavior
  • Cajal–Retzius cells
  • CXCL12
  • hippocampus
  • neurogenesis

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