Article Information
- Received June 18, 2025
- Revision received December 4, 2025
- Accepted December 16, 2025
- Published online January 14, 2026.
Author Information
- Rebekah van Bruggen1,*,
- Karla Manzanet Freyre1,*,
- Sangeetha Vasanthkumar1,*,
- Mi Wang1,* and
- Qiumin Tan1,2
- 1Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
- 2Women and Children’s Health Research Institute, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
- Correspondence should be addressed to Qiumin Tan at qiumin{at}ualberta.ca.
Author contributions
Author contributions: Q.T. designed research; R.v.B., K.M.F., S.V., and M.W. performed research; R.v.B., K.M.F., S.V., and M.W. analyzed data; R.v.B., K.M.F., S.V., M.W., and Q.T. wrote the paper.
Disclosures
The authors declare no competing financial interests.
We thank Dr. Alessandra Pierani (Université de Paris, Paris, France) for the generous gift of the ΔNp73-Cre transgenic mouse line. We also thank Dr. Sarah Hughes (University of Alberta) for her assistance with confocal microscopy. Qiumin Tan receives support from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2019-06153), the Canada Foundation for Innovation (Award 38985), and the Canadian Institutes of Health Research (MRC-177440 and PJT-178103). This study has been funded by the generosity of the Stollery Children's Hospital Foundation and the Alberta Women's Health Foundation through the Women and Children's Health Research Institute. Qiumin Tan is a Tier 2 Canada Research Chair in Neurodevelopmental Disorders. This study was undertaken, in part, thanks to funding from the Canada Research Chairs program.
↵*R.v.B., K.M.F., S.V., and M.W. contributed equally to this work.
Funding
Natural Sciences and Engineering Research Council of Canada (NSERC)
RGPIN‐2019‐06153Canada Foundation for Innovation (CFI)
Award 38985Canadian Institutes of Health Research (CIHR)
MRC‐177440; PJT‐178103Women and Children's Health Research Institute (WCHRI)
Canada Research Chairs (CRC)






