Article Information
- Received January 28, 2025
- Revision received December 10, 2025
- Accepted December 11, 2025
- Published online January 7, 2026.
Author Information
- Laura Tamberg1,*,
- Carl Sander Kiir1,*,
- Jürgen Tuvikene1,2,
- Käthy Rannaste1,
- Mari Palgi1,
- Indrek Koppel1 and
- Tõnis Timmusk1,2
- 1Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Harjumaa, Estonia
- 2Protobios LLC, Tallinn 12618, Harjumaa, Estonia
- Correspondence should be addressed to Laura Tamberg at laura.tamberg{at}taltech.ee or Tõnis Timmusk at tonis.timmusk{at}taltech.ee.
Author contributions
Author contributions: L.T., C.S.K., J.T., M.P., I.K., and T.T. designed research; L.T., C.S.K., and K.R. performed research; L.T., C.S.K., J.T., I.K., and T.T. analyzed data; L.T., C.S.K., J.T., M.P., I.K., and T.T. wrote the paper.
Disclosures
The authors declare no competing financial interests.
We thank Epp Väli for the technical assistance and the “TUT Institutional Development Program for 2016−2022” Graduate School in Clinical Medicine, which received funding from the European Regional Development Fund under program ASTRA 2014-2020.4.01.16-0032 in Estonia. Stocks obtained from the Bloomington Drosophila Stock Center (NIH P40OD018537) were used in this study. The simulations were carried out in the High Performance Computing Centre of TalTech. This study was supported by Estonian Research Council (grants PRG805 and PRG2583 to T.T., grant PRG2206 to I.K., and grant TARISTU24-TK14 to I.K. and T.T.), European Union through the European Regional Development Fund (project no. 2014-2020.4.01.15-0012 to T.T.), Pitt Hopkins Research Foundation and Million Dollar Bike Ride Pilot Grant Program for Rare Disease Research at the University of Pennsylvania Orphan Disease Center (grant MDBR-23-005-PittHopkins to T.T. and J.T.), and EC HORIZON-INFRA-2024-TECH-01-04 (project DTRIP4H no. 101188432 to TT).
↵*L.T. and C.S.K. contributed equally to this work.
Funding
Eesti Teadusagentuur (ETAG)
IUT19-18; PRG805EC | European Regional Development Fund (ERDF)
2014-2020.4.01.15-0012EC | H2020 | PRIORITY 'Excellent science' | H2020 Marie Skłodowska-Curie Actions-RISE-2016
EU734791Pitt Hopkins Research Foundation (PHRF)
grant no. 21
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