Release of Extracellular Matrix Components after Human Traumatic Brain Injury

The following authors have no conflict of interest to report: A.G.T., D.G., and M.P. The following authors do have reportable conflicts of interest: M.B., M.D.J., J.D.E., B.C., C.F., A-C.D., and K.J.S. M.B. reports support for the present manuscript from CURE/Department of Defense (DOD) # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy. M.D.J. reports support for the present manuscript from CURE/DOD # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy. In addition, in the past 36 months, M.D.J. received grants or contracts from NIH and Sontag Foundation and support for travel from CURE/DOD and participated on a data safety monitoring or advisory board for the Sontag Foundation. J.D.E. reports grants or contracts from NIH HL131474 and NS069566 and is a founder and consultant to TEGA Therapeutics. B.C. reports support for the present manuscript and travel funding from CURE/DOD # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy, NIH NINDS P01 NS127769 Changes in the ionic basis of GABAergic inhibition that contribute to post-traumatic epilepsy, and NIH R35 NS 116852 Neuronal ion and volume shifts after acute brain injury. B.C. reports grants or contracts from NIH NINDS P01 NS127769 Changes in the ionic basis of GABAergic inhibition that contribute to post-traumatic epilepsy. In addition, B.C. has received honoraria from medical schools for invited lectures in the past 36 months. C.F. reports the following grant: Genetic Study of Neurosurgical Developmental Abnormalities and Diseases (Protocol # 2021P001922 at MGH) Position full-time Senior CRC. A-C.D. reports support for the present manuscript from CURE/DOD # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy. In addition, A-C.D. reports the following grants or contracts from the past 36 months: TRACK-TBI LONG, UCSF, Long-term outcomes after traumatic brain injury in children enrolled in TRACK-TBI; capitated study; no salary support; Salata Institute, Harvard University, Effects of Peak Power Plant on Health of Local Population, 0.6% calendar months (5% FTE). A-C.D. receives royalties from their book, “Minding the Climate,” Harvard University Press, 2022, and participates on the Board of Directors (unpaid volunteer position) of the Audubon Society of Rhode Island. K.J.S. reports support of the present manuscript from CURE/DOD # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy, NIH NINDS P01 NS127769 Changes in the ionic basis of GABAergic inhibition that contribute to post-traumatic epilepsy, and NIH R35 NS 116852 Neuronal ion and volume shifts after acute brain injury. In the past 36 months, K.J.S. reports grants or contracts from NIH NINDS P01 NS127769 Changes in the ionic basis of GABAergic inhibition that contribute to post-traumatic epilepsy. In addition, K.J.S. received honoraria from medical schools for invited lectures and support for attending meetings and/or travel from CURE/DOD # W81XWH-15-2-0069 The role of extracellular matrix injury in post-traumatic epilepsy, NIH NINDS P01 NS127769 Changes in the ionic basis of GABAergic inhibition that contribute to post-traumatic epilepsy, and NIH R35 NS 116852 Neuronal ion and volume shifts after acute brain injury.

We acknowledge the assistance of the critical care and nursing staff in the intensive care units and the clinical laboratory staff where patient samples were collected. This work was supported by Citizens United for Research in Epilepsy (W81XWH-15-2-0069).