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Research ArticleResearch Article: New Research, Neuronal Excitability

Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine

Omar Koita, Joseph J. Lebowitz and John T. Williams
eNeuro 2 June 2025, 12 (6) ENEURO.0249-24.2025; https://doi.org/10.1523/ENEURO.0249-24.2025
Omar Koita
Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
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Joseph J. Lebowitz
Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
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John T. Williams
Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0249-24.2025
PubMed 
40456612
Published By 
Society for Neuroscience
History 
  • Received June 9, 2024
  • Revision received April 21, 2025
  • Accepted April 30, 2025
  • Published online June 2, 2025.
Copyright & Usage 
Copyright © 2025 Koita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Omar Koita,
  2. Joseph J. Lebowitz and
  3. John T. Williams
  1. Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239
  1. Correspondence should be addressed to John T. Williams at williamj{at}ohsu.edu.
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Author contributions

  1. Author contributions: O.K., J.J.L., and J.T.W. designed research; O.K. and J.J.L. performed research; O.K. and J.J.L. analyzed data; O.K., J.J.L., and J.T.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health DA04523 (J.T.W.) and F99NS129176 (O.K.). We thank Marina Wolf for providing MOR-Cre × tdTomato rats for imaging experiments. We thank Seksiri Arttamangkul and Skyler Jackman for helpful comments on the analysis and presentation of this work.

Funding

  • NIH NIDA

    DA04523
  • HHS | NIH | NIH Blueprint for Neuroscience Research (NIH Blueprint)

    F99NS129176

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eneuro: 12 (6)
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June 2025
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Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine
Omar Koita, Joseph J. Lebowitz, John T. Williams
eNeuro 2 June 2025, 12 (6) ENEURO.0249-24.2025; DOI: 10.1523/ENEURO.0249-24.2025

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Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine
Omar Koita, Joseph J. Lebowitz, John T. Williams
eNeuro 2 June 2025, 12 (6) ENEURO.0249-24.2025; DOI: 10.1523/ENEURO.0249-24.2025
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Keywords

  • desensitization
  • morphine
  • neuronal excitability
  • opioids
  • tolerance
  • withdrawal

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