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Research ArticleResearch Article: New Research, Cognition and Behavior

Increasing H2B Monoubiquitination Improves the Transcriptome and Memory in the Aged Hippocampus

Shannon Kincaid, Gueladouan Setenet, Natalie J. Preveza, Kaiser C. Arndt, Phillip Gwin, Yu Lin, Hehuang Xie and Timothy J. Jarome
eNeuro 7 April 2025, 12 (4) ENEURO.0037-25.2025; https://doi.org/10.1523/ENEURO.0037-25.2025
Shannon Kincaid
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Gueladouan Setenet
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Natalie J. Preveza
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Kaiser C. Arndt
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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  • ORCID record for Kaiser C. Arndt
Phillip Gwin
2School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Yu Lin
3Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Hehuang Xie
2School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
3Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
4Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Timothy J. Jarome
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
2School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0037-25.2025
PubMed 
40194842
Published By 
Society for Neuroscience
History 
  • Received January 22, 2025
  • Revision received March 25, 2025
  • Accepted March 28, 2025
  • Published online April 7, 2025.
Copyright & Usage 
Copyright © 2025 Kincaid et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Shannon Kincaid1,
  2. Gueladouan Setenet1,
  3. Natalie J. Preveza1,
  4. Kaiser C. Arndt1,
  5. Phillip Gwin2,
  6. Yu Lin3,
  7. Hehuang Xie2,3,4 and
  8. Timothy J. Jarome1,2
  1. 1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
  2. 2School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
  3. 3Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
  4. 4Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061
  1. Correspondence should be addressed to Timothy J. Jarome at tjjarome{at}vt.edu.
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Author contributions

  1. Author contributions: S.K. and T.J.J. designed research; S.K., G.S., N.J.P., K.C.A., and P.G. performed research; S.K., Y.L., and H.X. analyzed data; S.K. and T.J.J. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants AG081851, AG071523, AG079292, MH122414, and MH131587 to T.J.J. The funders had no role in the study design, data interpretation or decision to publish.

Funding

  • HHS | NIH | National Institute on Aging (NIA)

    AG081851
  • HHS | NIH | National Institute of Mental Health (NIMH)

    MH122414

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  • You are viewing the most recent version of this article.
  • previous version (April 07, 2025).

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AbstractFullPdf
Apr 2025363414241
May 20255417450
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eneuro: 12 (4)
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April 2025
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Increasing H2B Monoubiquitination Improves the Transcriptome and Memory in the Aged Hippocampus
Shannon Kincaid, Gueladouan Setenet, Natalie J. Preveza, Kaiser C. Arndt, Phillip Gwin, Yu Lin, Hehuang Xie, Timothy J. Jarome
eNeuro 7 April 2025, 12 (4) ENEURO.0037-25.2025; DOI: 10.1523/ENEURO.0037-25.2025

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Increasing H2B Monoubiquitination Improves the Transcriptome and Memory in the Aged Hippocampus
Shannon Kincaid, Gueladouan Setenet, Natalie J. Preveza, Kaiser C. Arndt, Phillip Gwin, Yu Lin, Hehuang Xie, Timothy J. Jarome
eNeuro 7 April 2025, 12 (4) ENEURO.0037-25.2025; DOI: 10.1523/ENEURO.0037-25.2025
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Keywords

  • aging
  • hippocampus
  • histone H2B
  • monoubiquitination
  • transcriptome

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