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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Dual Role of A2aR in Neuroinflammation: Modulating Microglial Polarization in White Matter Lesions

Chang Cheng, Wenchao Cheng, Yuhan Wang, Xiuying Chen, Lan Zhang, Yi Li, Fa Shen, Dezhi Yuan, Pian Hong and Wen Huang
eNeuro 13 February 2025, 12 (3) ENEURO.0579-24.2025; https://doi.org/10.1523/ENEURO.0579-24.2025
Chang Cheng
1Department of Neurology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing CN 400037, China
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Wenchao Cheng
3Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan CN 450052, China
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Yuhan Wang
3Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan CN 450052, China
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Xiuying Chen
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Lan Zhang
4Department of Neurology, Nanchong Central Hospital, Nanchong, Sichuan CN 634700, China
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Yi Li
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Fa Shen
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Dezhi Yuan
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Pian Hong
5Department of Endocrinology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing CN 400037, China
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Wen Huang
1Department of Neurology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing CN 400037, China
2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0579-24.2025
PubMed 
39947902
Published By 
Society for Neuroscience
History 
  • Received December 19, 2024
  • Accepted February 4, 2025
  • Published online February 13, 2025.
Copyright & Usage 
Copyright © 2025 Cheng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Chang Cheng1,2,*,
  2. Wenchao Cheng3,*,
  3. Yuhan Wang3,*,
  4. Xiuying Chen2,
  5. Lan Zhang4,
  6. Yi Li2,
  7. Fa Shen2,
  8. Dezhi Yuan2,
  9. Pian Hong5 and
  10. Wen Huang1,2
  1. 1Department of Neurology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing CN 400037, China
  2. 2Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing CN 400014, China
  3. 3Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan CN 450052, China
  4. 4Department of Neurology, Nanchong Central Hospital, Nanchong, Sichuan CN 634700, China
  5. 5Department of Endocrinology, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing CN 400037, China
  1. Correspondence should be addressed to Wen Huang at Wenhuangchongqing{at}163.com.
View Full Text

Author contributions

  1. Author contributions: C.C., W.C., Y.W., and W.H. designed research; C.C., W.C., Y.L., F.S., and D.Y. performed research; W.H. contributed unpublished reagents/analytic tools; X.C., L.Z., and P.H. analyzed data; C.C., W.C., and Y.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This study was supported by funds from the National Natural Science Foundation of China (Grant No. 82171334), Chongqing Natural Science Foundation (Grant No. CSTB2024NSCQ-MSX0573), and the Chongqing Science and Health Joint Medical Research Project (Grant No. 2023ZDXM016).

  • ↵*C.C., W.C., and Y.W. contributed equally to this work.

Funding

  • the National Natural Science Foundation of China

    No. 82171334
  • Chongqing Science and Health Joint Medical Research Project

    No. 2023ZDXM016
  • Chongqing Natural Science Foudation

    CSTB2024NSCQ-MSX0573

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  • previous version (February 13, 2025).

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The Dual Role of A2aR in Neuroinflammation: Modulating Microglial Polarization in White Matter Lesions
Chang Cheng, Wenchao Cheng, Yuhan Wang, Xiuying Chen, Lan Zhang, Yi Li, Fa Shen, Dezhi Yuan, Pian Hong, Wen Huang
eNeuro 13 February 2025, 12 (3) ENEURO.0579-24.2025; DOI: 10.1523/ENEURO.0579-24.2025

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The Dual Role of A2aR in Neuroinflammation: Modulating Microglial Polarization in White Matter Lesions
Chang Cheng, Wenchao Cheng, Yuhan Wang, Xiuying Chen, Lan Zhang, Yi Li, Fa Shen, Dezhi Yuan, Pian Hong, Wen Huang
eNeuro 13 February 2025, 12 (3) ENEURO.0579-24.2025; DOI: 10.1523/ENEURO.0579-24.2025
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Keywords

  • A2aR
  • A2aR–mGluR5 heteromer
  • chronic cerebral hypoperfusion
  • microglia
  • neuroinflammation

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