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Research ArticleResearch Article: New Research, Novel Tools and Methods

Postmortem Interval Leads to Loss of Disease-Specific Signatures in Brain Tissue

Kimberly C. Olney, Katelin A. Gibson, Mika P. Cadiz, Negin Rahimzadeh, Vivek Swarup and John D. Fryer
eNeuro 27 February 2025, 12 (3) ENEURO.0505-24.2025; https://doi.org/10.1523/ENEURO.0505-24.2025
Kimberly C. Olney
1Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona 85259
2Translational Genomics Research Institute (TGen), Phoenix, Arizona 85004
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Katelin A. Gibson
1Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona 85259
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Mika P. Cadiz
1Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona 85259
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Negin Rahimzadeh
3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
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Vivek Swarup
3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
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John D. Fryer
1Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona 85259
2Translational Genomics Research Institute (TGen), Phoenix, Arizona 85004
4Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Scottsdale, Arizona 85259
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0505-24.2025
PubMed 
40015966
Published By 
Society for Neuroscience
History 
  • Received November 1, 2024
  • Revision received January 13, 2025
  • Accepted January 16, 2025
  • Published online February 27, 2025.
Copyright & Usage 
Copyright © 2025 Olney et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kimberly C. Olney1,2,*,
  2. Katelin A. Gibson1,*,
  3. Mika P. Cadiz1,*,
  4. Negin Rahimzadeh3,
  5. Vivek Swarup3 and
  6. John D. Fryer1,2,4
  1. 1Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona 85259
  2. 2Translational Genomics Research Institute (TGen), Phoenix, Arizona 85004
  3. 3Department of Neurobiology and Behavior, University of California, Irvine, California 92697
  4. 4Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Scottsdale, Arizona 85259
  1. Correspondence should be addressed to Kimberly C. Olney at kolney{at}tgen.org or John D. Fryer at jfryer@tgen.org.
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Author contributions

  1. Author contributions: K.A.G., M.P.C., and J.D.F. designed research; K.A.G. and M.P.C. performed research; K.C.O., N.R., V.S., and J.D.F. analyzed data; K.C.O., K.A.G., and J.D.F. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • ↵*K.C.O., K.A.G., and M.P.C. contributed equally to this work.

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Postmortem Interval Leads to Loss of Disease-Specific Signatures in Brain Tissue
Kimberly C. Olney, Katelin A. Gibson, Mika P. Cadiz, Negin Rahimzadeh, Vivek Swarup, John D. Fryer
eNeuro 27 February 2025, 12 (3) ENEURO.0505-24.2025; DOI: 10.1523/ENEURO.0505-24.2025

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Postmortem Interval Leads to Loss of Disease-Specific Signatures in Brain Tissue
Kimberly C. Olney, Katelin A. Gibson, Mika P. Cadiz, Negin Rahimzadeh, Vivek Swarup, John D. Fryer
eNeuro 27 February 2025, 12 (3) ENEURO.0505-24.2025; DOI: 10.1523/ENEURO.0505-24.2025
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Keywords

  • gene expression
  • postmortem interval
  • single nucleus

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