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Research ArticleResearch Article: New Research, Development

Prenatal Ethanol Exposure Results in Cell Type, Age, and Sex-Dependent Differences in the Neonatal Striatum That Coincide with Early Motor Deficits

Adelaide R. Tousley, Ilana Deykin, Betul Koc, Pamela W. L. Yeh and Hermes H. Yeh
eNeuro 14 March 2025, 12 (3) ENEURO.0448-24.2025; https://doi.org/10.1523/ENEURO.0448-24.2025
Adelaide R. Tousley
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
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Ilana Deykin
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
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Betul Koc
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
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Pamela W. L. Yeh
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
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Hermes H. Yeh
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0448-24.2025
PubMed 
40086875
Published By 
Society for Neuroscience
History 
  • Received October 21, 2024
  • Revision received February 5, 2025
  • Accepted February 26, 2025
  • Published online March 14, 2025.
Copyright & Usage 
Copyright © 2025 Tousley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Adelaide R. Tousley,
  2. Ilana Deykin,
  3. Betul Koc,
  4. Pamela W. L. Yeh and
  5. Hermes H. Yeh
  1. Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755
  1. Correspondence should be addressed to Hermes H. Yeh at hermes.yeh{at}dartmouth.edu.
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Author contributions

  1. Author contributions: H.H.Y., A.R.T., and P.W.L.Y. designed research; A.R.T. and P.W.L.Y. performed research; A.R.T., I.D., and B.K. analyzed data; H.H.Y., A.R.T., and P.W.L.Y. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health grants R01AG072900 and R01AA027754 to H.H.Y. and F30AA029261 to A.R.T.

Funding

  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    R01 AA027754; F30 AA029261
  • HHS | NIH | National Institute on Aging (NIA)

    R01 AG072900

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  • previous version (March 14, 2025).

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Mar 2025255146205
Apr 20254822862
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eneuro: 12 (3)
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March 2025
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Prenatal Ethanol Exposure Results in Cell Type, Age, and Sex-Dependent Differences in the Neonatal Striatum That Coincide with Early Motor Deficits
Adelaide R. Tousley, Ilana Deykin, Betul Koc, Pamela W. L. Yeh, Hermes H. Yeh
eNeuro 14 March 2025, 12 (3) ENEURO.0448-24.2025; DOI: 10.1523/ENEURO.0448-24.2025

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Prenatal Ethanol Exposure Results in Cell Type, Age, and Sex-Dependent Differences in the Neonatal Striatum That Coincide with Early Motor Deficits
Adelaide R. Tousley, Ilana Deykin, Betul Koc, Pamela W. L. Yeh, Hermes H. Yeh
eNeuro 14 March 2025, 12 (3) ENEURO.0448-24.2025; DOI: 10.1523/ENEURO.0448-24.2025
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Keywords

  • alcohol
  • GABAergic interneurons
  • motor behavior
  • mouse model of FASD
  • spiny projection neurons

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