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Research ArticleResearch Article: Confirmation, Cognition and Behavior

Cocaine Self-Administration Increases Impulsive Decision-Making in Low-Impulsive Rats Associated with Impaired Functional Connectivity in the Mesocorticolimbic System

Hui Shen, Zilu Ma, Emma Hans, Ying Duan, Guo-Hua Bi, Yurim C. Chae, Robbie Y. Kuang, Zheng-Xiong Xi and Yihong Yang
eNeuro 3 March 2025, 12 (3) ENEURO.0408-24.2025; https://doi.org/10.1523/ENEURO.0408-24.2025
Hui Shen
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Zilu Ma
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Emma Hans
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Ying Duan
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Guo-Hua Bi
2Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Yurim C. Chae
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Robbie Y. Kuang
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Zheng-Xiong Xi
2Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Yihong Yang
1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0408-24.2025
PubMed 
40032530
Published By 
Society for Neuroscience
History 
  • Received September 18, 2024
  • Revision received December 22, 2024
  • Accepted January 26, 2025
  • Published online March 3, 2025.
Copyright & Usage 
Copyright © 2025 Shen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hui Shen1,*,
  2. Zilu Ma1,*,
  3. Emma Hans1,
  4. Ying Duan1,
  5. Guo-Hua Bi2,
  6. Yurim C. Chae1,
  7. Robbie Y. Kuang1,
  8. Zheng-Xiong Xi2 and
  9. Yihong Yang1
  1. 1Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
  2. 2Addiction Biology Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224
  1. Correspondence should be addressed to Yihong Yang at yihongyang{at}intra.nida.nih.gov or Zheng-Xiong Xi at zxi{at}intra.nida.nih.gov.
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Author contributions

  1. Author contributions: H.S., Z.M., Y.D., Z-X.X., and Y.Y. designed research; H.S., Z.M., E.H., Y.D., G-H.B., Y.C.C., and R.Y.K. performed research; H.S., Z.M., E.H., Z-X.X., and Y.Y. analyzed data; H.S., Z-X.X., and Y.Y. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Intramural Research Program at the National Institute on Drug Abuse (NIDA-IRP), Neuroimaging Research Branch (Z1A DA000638, Y.Y.) and Addiction Biology Unit of Molecular Targets and Medications Discovery Branch (Z1A DA000633, Z-X.X.).

  • ↵*H.S. and Z.M. contributed equally to this work.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    Z1A DA000638; Z1A DA000633

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Cocaine Self-Administration Increases Impulsive Decision-Making in Low-Impulsive Rats Associated with Impaired Functional Connectivity in the Mesocorticolimbic System
Hui Shen, Zilu Ma, Emma Hans, Ying Duan, Guo-Hua Bi, Yurim C. Chae, Robbie Y. Kuang, Zheng-Xiong Xi, Yihong Yang
eNeuro 3 March 2025, 12 (3) ENEURO.0408-24.2025; DOI: 10.1523/ENEURO.0408-24.2025

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Cocaine Self-Administration Increases Impulsive Decision-Making in Low-Impulsive Rats Associated with Impaired Functional Connectivity in the Mesocorticolimbic System
Hui Shen, Zilu Ma, Emma Hans, Ying Duan, Guo-Hua Bi, Yurim C. Chae, Robbie Y. Kuang, Zheng-Xiong Xi, Yihong Yang
eNeuro 3 March 2025, 12 (3) ENEURO.0408-24.2025; DOI: 10.1523/ENEURO.0408-24.2025
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Keywords

  • choice impulsivity
  • cocaine self-administration
  • dopamine receptors
  • functional connectivity
  • functional MRI
  • reward delay discounting

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