Article Information
- Received January 2, 2024
- Revision received December 6, 2024
- Accepted January 9, 2025
- Published online February 11, 2025.
Author Information
- Anastazja M. Gorecki1,2,*,
- Jared Slosberg3,*,
- Su Min Hong4,
- Philippa Seika4,
- Srinivas N. Puttapaka4,
- Blake Migden4,
- Anton Gulko5,
- Alpana Singh6,
- Chengxiu Zhang6,
- Rohin Gurumurthy6 and
- Subhash Kulkarni4,7,8
- 1Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia
- 2School of Biological Sciences, University of Western Australia, Crawley, Western Australia 6009, Australia
- 3Department of Genetic Medicine, Johns Hopkins University – School of Medicine, Baltimore, Maryland 21205
- 4Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115
- 5Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115
- 6Center for Neurogastroenterology, Department of Medicine, Johns Hopkins University–School of Medicine, Baltimore, Maryland 21205
- 7Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts 02115
- 8Program in Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
- Correspondence should be addressed to Subhash Kulkarni at skulkar1{at}bidmc.harvard.edu.
Author contributions
Author contributions: A.M.G., J.S., and S.K. designed research; A.M.G., J.S., S.M.H., P.S., S.N.P., B.M., A.G., A.S., C.Z., R.G., and S.K. performed research; A.M.G. contributed unpublished reagents/analytic tools; S.K. analyzed data; J.S. and S.K. wrote the paper.
Disclosures
The authors declare no competing financial interests.
This work was supported by funding from NIA R01AG66768, R21AG072107, Diacomp Foundation (Pilot award Augusta University) and Pilot Grant from the Harvard Digestive Disease Core (S.K.). A.M.G. was supported by a Fulbright Future Scholarship, funded by The Kinghorn Foundation. J.S. was funded through the Maryland Genetics, Epidemiology, and Medicine training program sponsored by the Burroughs Welcome Fund and from Walter Benjamin Fellowship (528835020) from Deutsche Forschungsgemeinschaft (P.S.). A.G. and the nuclear isolation at BIDMC was supported by the center grant from NIDDK P30DK135043. We acknowledge the help of Mr. John Tigges, Technical Director/Manager Flow Cytometry Science Center, Beth Israel Deaconess Medical Center, for his help with flow cytometric analyses on FlowJo. We appreciate the help of Dr. Taru Muranen and Dr. Nina Kozlova for their help with FlowJo.
↵*A.M.G. and J.S. are co-first authors.
Funding
HHS | NIH | National Institute on Aging (NIA)
R01AG66767National Institute on Aging
R21AG072107Diacomp
Pilot FundingHarvard Digestive Disease Core
Pilot FundingThe Kinghorn Foundation
Fulbright FuturesBurroughs Welcome Fund
Maryland GeneticsDeutsche Forschungsgemeinschaft (DFG)
Walter Benjamin Fellowship (528835020)
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