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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Sex-Specific Age-Related Changes in Excitatory and Inhibitory Intracortical Circuits in Mouse Primary Auditory Cortex

Zheng Xu, Binghan Xue, Joseph P. Y. Kao and Patrick O. Kanold
eNeuro 3 December 2024, 12 (2) ENEURO.0378-24.2024; https://doi.org/10.1523/ENEURO.0378-24.2024
Zheng Xu
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 20215
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Binghan Xue
2Department of Biology, University of Maryland, College Park, Maryland 20742
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Joseph P. Y. Kao
3Center for Biomedical Engineering and Technology, and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201
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Patrick O. Kanold
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 20215
2Department of Biology, University of Maryland, College Park, Maryland 20742
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0378-24.2024
PubMed 
39626952
Published By 
Society for Neuroscience
History 
  • Received August 30, 2024
  • Accepted November 11, 2024
  • Published online December 3, 2024.
Copyright & Usage 
Copyright © 2025 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Zheng Xu1,
  2. Binghan Xue2,
  3. Joseph P. Y. Kao3 and
  4. Patrick O. Kanold1,2
  1. 1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 20215
  2. 2Department of Biology, University of Maryland, College Park, Maryland 20742
  3. 3Center for Biomedical Engineering and Technology, and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201
  1. Correspondence should be addressed to Patrick O. Kanold at pkanold{at}jhu.edu.
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Author contributions

  1. Author contributions: P.O.K. designed research; Z.X. and B.X. performed research; J.P.Y.K. contributed unpublished reagents/analytic tools; Z.X. and B.X. analyzed data; Z.X., B.X., and P.O.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health (NIH) RF1AG078378 (P.O.K), NIH P01AG055365 (P.O.K), NIH RO1DC009607 (P.O.K), NIH R01GM056481 (J.P.Y.K).

Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    RO1DC009607
  • HHS | NIH | National Institute on Aging (NIA)

    RF1AG078378; RO1DC009607
  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    R01GM056481

Other Version

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  • previous version (December 03, 2024).

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February 2025
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Sex-Specific Age-Related Changes in Excitatory and Inhibitory Intracortical Circuits in Mouse Primary Auditory Cortex
Zheng Xu, Binghan Xue, Joseph P. Y. Kao, Patrick O. Kanold
eNeuro 3 December 2024, 12 (2) ENEURO.0378-24.2024; DOI: 10.1523/ENEURO.0378-24.2024

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Sex-Specific Age-Related Changes in Excitatory and Inhibitory Intracortical Circuits in Mouse Primary Auditory Cortex
Zheng Xu, Binghan Xue, Joseph P. Y. Kao, Patrick O. Kanold
eNeuro 3 December 2024, 12 (2) ENEURO.0378-24.2024; DOI: 10.1523/ENEURO.0378-24.2024
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Keywords

  • aging
  • excitation
  • GABA
  • inhibition
  • primary auditory cortex
  • translaminar circuits

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