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Research ArticleResearch Article: New Research, Cognition and Behavior

Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats

Alexandra Scott, Anika Paulson, Collin Prill, Klaiten Kermoade, Bailey Newell, Elizabeth A. Eckenwiler, Julia C. Lemos and Jocelyn M. Richard
eNeuro 14 January 2025, 12 (2) ENEURO.0245-24.2025; https://doi.org/10.1523/ENEURO.0245-24.2025
Alexandra Scott
1Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
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Anika Paulson
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
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Collin Prill
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
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Klaiten Kermoade
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
4Molecular Pharmacological and Therapeutics, University of Minnesota, Minneapolis, Minnesota
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Bailey Newell
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
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  • ORCID record for Bailey Newell
Elizabeth A. Eckenwiler
1Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
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Julia C. Lemos
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
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Jocelyn M. Richard
2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0245-24.2025
PubMed 
39809537
Published By 
Society for Neuroscience
History 
  • Received June 7, 2024
  • Revision received November 5, 2024
  • Accepted January 6, 2025
  • Published online January 14, 2025.
Copyright & Usage 
Copyright © 2025 Scott et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexandra Scott1,2,*,
  2. Anika Paulson2,3,*,
  3. Collin Prill2,3,*,
  4. Klaiten Kermoade3,4,
  5. Bailey Newell2,3,
  6. Elizabeth A. Eckenwiler1,2,
  7. Julia C. Lemos2,3 and
  8. Jocelyn M. Richard2,3
  1. 1Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota
  2. 2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, Minnesota
  3. 3Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota
  4. 4Molecular Pharmacological and Therapeutics, University of Minnesota, Minneapolis, Minnesota
  1. Correspondence should be addressed to Jocelyn M. Richard at richardj{at}umn.edu.
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Author contributions

  1. Author contributions: A.S., E.A.E., J.C.L., and J.M.R. designed research; A.S., A.P., C.P., K.K., B.N., E.A.E., and J.M.R. performed research; A.S., A.P., C.P., E.A.E., J.C.L., and J.M.R. analyzed data; A.S., A.P., C.P., E.A.E., and J.M.R. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Some viral vectors used in this study were generated by the University of Minnesota Viral Innovation Core, and some fluorescence images were taken at the University of Minnesota University Imaging Centers. This work was supported by the National Institutes of Health Grants R01DA053208 to J.M.R., F31AA031597 to K.K., F31DA059436 to E.A.E., and P30DA048742 and a MnDRIVE Graduate Fellowship in Neuromodulation to A.S.

  • ↵*A.S., A.P., and C.P. contributed equally to this work.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    R01DA053208; F31DA059436; P30DA048742
  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    F31AA031597

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Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats
Alexandra Scott, Anika Paulson, Collin Prill, Klaiten Kermoade, Bailey Newell, Elizabeth A. Eckenwiler, Julia C. Lemos, Jocelyn M. Richard
eNeuro 14 January 2025, 12 (2) ENEURO.0245-24.2025; DOI: 10.1523/ENEURO.0245-24.2025

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Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats
Alexandra Scott, Anika Paulson, Collin Prill, Klaiten Kermoade, Bailey Newell, Elizabeth A. Eckenwiler, Julia C. Lemos, Jocelyn M. Richard
eNeuro 14 January 2025, 12 (2) ENEURO.0245-24.2025; DOI: 10.1523/ENEURO.0245-24.2025
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Keywords

  • chemogenetic
  • consumption
  • sex differences
  • sucrose
  • ventral pallidum

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