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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and Anxiety-Like Behaviors

Fariya Zaheer, Gabriel J. Levine, Ana Leticia Simal, Seyed Reza Fatemi Tabatabaei, Tami A. Martino and Giannina Descalzi
eNeuro 14 January 2025, 12 (2) ENEURO.0244-24.2024; https://doi.org/10.1523/ENEURO.0244-24.2024
Fariya Zaheer
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Gabriel J. Levine
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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  • ORCID record for Gabriel J. Levine
Ana Leticia Simal
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Seyed Reza Fatemi Tabatabaei
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
2Center for Cardiovascular Investigations, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Tami A. Martino
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
2Center for Cardiovascular Investigations, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Giannina Descalzi
1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0244-24.2024
PubMed 
39809538
Published By 
Society for Neuroscience
History 
  • Received June 2, 2024
  • Revision received December 18, 2024
  • Accepted December 23, 2024
  • Published online January 14, 2025.
Copyright & Usage 
Copyright © 2025 Zaheer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Fariya Zaheer1,
  2. Gabriel J. Levine1,
  3. Ana Leticia Simal1,
  4. Seyed Reza Fatemi Tabatabaei1,2,
  5. Tami A. Martino1,2 and
  6. Giannina Descalzi1
  1. 1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
  2. 2Center for Cardiovascular Investigations, University of Guelph, Guelph, Ontario N1G 2W1, Canada
  1. Correspondence should be addressed to Giannina Descalzi at gdescalz{at}uoguelph.ca.
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Author contributions

  1. Author contributions: F.Z., G.J.L., A.L.S., and G.D. designed research; F.Z., G.J.L., A.L.S., and G.D. performed research; S.R.F.T. and T.A.M. contributed unpublished reagents/analytic tools; F.Z., G.J.L., A.L.S., and G.D. analyzed data; F.Z., G.J.L., T.A.M., and G.D. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by an NSERC Discovery Grant (RGPIN-2020-04000), a CIHR Project Grant (ID 191827), and a Canadian Foundation for Innovation John R. Evans Leaders Fund Grant (#461090) awarded to G.D.

Funding

  • NSERC

    RGPIN-2020-04000

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Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and Anxiety-Like Behaviors
Fariya Zaheer, Gabriel J. Levine, Ana Leticia Simal, Seyed Reza Fatemi Tabatabaei, Tami A. Martino, Giannina Descalzi
eNeuro 14 January 2025, 12 (2) ENEURO.0244-24.2024; DOI: 10.1523/ENEURO.0244-24.2024

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Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and Anxiety-Like Behaviors
Fariya Zaheer, Gabriel J. Levine, Ana Leticia Simal, Seyed Reza Fatemi Tabatabaei, Tami A. Martino, Giannina Descalzi
eNeuro 14 January 2025, 12 (2) ENEURO.0244-24.2024; DOI: 10.1523/ENEURO.0244-24.2024
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Keywords

  • anxiety
  • autophagy
  • BECLIN-1
  • female
  • neuropathic pain
  • sex differences

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