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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Deciphering Compromised Speech-in-Noise Intelligibility in Older Listeners: The Role of Cochlear Synaptopathy

Markus Garrett, Viacheslav Vasilkov, Manfred Mauermann, Pauline Devolder, John L. Wilson, Leslie Gonzales, Kenneth S. Henry and Sarah Verhulst
eNeuro 9 January 2025, 12 (2) ENEURO.0182-24.2024; https://doi.org/10.1523/ENEURO.0182-24.2024
Markus Garrett
1Medizinische Physik and Cluster of Excellence “Hearing4all”, Department of Medical Physics and Acoustics, Carl von Ossietzky University of Oldenburg, Oldenburg 26129, Germany
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Viacheslav Vasilkov
2Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Zwijnaarde 9052, Belgium
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Manfred Mauermann
1Medizinische Physik and Cluster of Excellence “Hearing4all”, Department of Medical Physics and Acoustics, Carl von Ossietzky University of Oldenburg, Oldenburg 26129, Germany
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Pauline Devolder
2Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Zwijnaarde 9052, Belgium
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John L. Wilson
3Department of Otolaryngology, University of Rochester, Rochester, New York 14642
4Department of Neuroscience, University of Rochester, Rochester, New York 14642
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Leslie Gonzales
4Department of Neuroscience, University of Rochester, Rochester, New York 14642
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Kenneth S. Henry
3Department of Otolaryngology, University of Rochester, Rochester, New York 14642
4Department of Neuroscience, University of Rochester, Rochester, New York 14642
5Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627
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Sarah Verhulst
2Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Zwijnaarde 9052, Belgium
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0182-24.2024
PubMed 
39788732
Published By 
Society for Neuroscience
History 
  • Received April 29, 2024
  • Revision received November 29, 2024
  • Accepted December 16, 2024
  • Published online January 9, 2025.
Copyright & Usage 
Copyright © 2025 Garrett et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Markus Garrett1,*,
  2. Viacheslav Vasilkov2,*,
  3. Manfred Mauermann1,
  4. Pauline Devolder2,
  5. John L. Wilson3,4,
  6. Leslie Gonzales4,
  7. Kenneth S. Henry3,4,5 and
  8. Sarah Verhulst2
  1. 1Medizinische Physik and Cluster of Excellence “Hearing4all”, Department of Medical Physics and Acoustics, Carl von Ossietzky University of Oldenburg, Oldenburg 26129, Germany
  2. 2Hearing Technology @ WAVES, Department of Information Technology, Ghent University, Zwijnaarde 9052, Belgium
  3. 3Department of Otolaryngology, University of Rochester, Rochester, New York 14642
  4. 4Department of Neuroscience, University of Rochester, Rochester, New York 14642
  5. 5Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627
  1. Correspondence should be addressed to Sarah Verhulst at s.verhulst{at}ugent.be.
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Author contributions

  1. Author contributions: M.G., V.V., M.M., and S.V. designed research; M.G., V.V., J.L.W., L.G., and K.S.H. performed research; M.G., V.V., M.M., P.D., J.L.W., L.G., K.S.H., and S.V. analyzed data; M.G., P.D., and S.V. wrote the paper.

Disclosures

  • Ghent University owns a patent (US Patent App. 17/791,985) related to the RAM-EFR methods adopted in this paper. Sarah Verhulst and Viacheslav Vasilkov are inventors.

  • This work was supported by the DFG Cluster of Excellence EXC 1077/1 “Hearing4all” (MG, MM, SV), the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme (grant agreement No 678120 RobSpear; VV, SV) and European Innovation Council (EIC-Transition EarDiTech 101058278; SV), National Institutes of Health grant R01 DC017519 (KH) and a National Institutes of Health Predoctoral National Research Service Award Fellowship (TL1 TR002000) administered by the University of Rochester Clinical and Translational Science Institute (JW).

  • The authors would like to thank the study participants as well as the Hörzentrum Oldenburg for helping with participant recruitment. Lastly, we thank Sarineh Keshishzadeh for help with the analysis scripts and data storage and labelling throughout the project and Attila Fráter for help with the reanalysis of the Encina-llamas data.

  • ↵*These authors contributed equally to the work.

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    EXC 1077/1
  • EC | ERC | HORIZON EUROPE European Research Council (ERC)

    678120
  • HHS | National Institutes of Health (NIH)

    R01 DC017519; TL1 TR002000

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Deciphering Compromised Speech-in-Noise Intelligibility in Older Listeners: The Role of Cochlear Synaptopathy
Markus Garrett, Viacheslav Vasilkov, Manfred Mauermann, Pauline Devolder, John L. Wilson, Leslie Gonzales, Kenneth S. Henry, Sarah Verhulst
eNeuro 9 January 2025, 12 (2) ENEURO.0182-24.2024; DOI: 10.1523/ENEURO.0182-24.2024

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Deciphering Compromised Speech-in-Noise Intelligibility in Older Listeners: The Role of Cochlear Synaptopathy
Markus Garrett, Viacheslav Vasilkov, Manfred Mauermann, Pauline Devolder, John L. Wilson, Leslie Gonzales, Kenneth S. Henry, Sarah Verhulst
eNeuro 9 January 2025, 12 (2) ENEURO.0182-24.2024; DOI: 10.1523/ENEURO.0182-24.2024
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Keywords

  • cochlear synaptopathy
  • envelope-following response
  • outer hair cell damage
  • reception threshold
  • sensorineural hearing loss
  • speech-in-noise
  • speech
  • speech intelligibility

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