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Research ArticleResearch Article: New Research, Neuronal Excitability

Individual Variation in Intrinsic Neuronal Properties of Nucleus Accumbens Core and Shell Medium Spiny Neurons in Male Rats Prone to Sign- or Goal-Track

Cristina E. María-Ríos, Geoffrey G. Murphy and Jonathan D. Morrow
eNeuro 1 December 2025, 12 (12) ENEURO.0203-25.2025; https://doi.org/10.1523/ENEURO.0203-25.2025
Cristina E. María-Ríos
1Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
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Geoffrey G. Murphy
1Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
2Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109
3Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109
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Jonathan D. Morrow
1Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
2Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109
4Psychiatry, University of Michigan, Ann Arbor, Michigan 48109
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0203-25.2025
PubMed 
41326204
Published By 
Society for Neuroscience
History 
  • Received May 23, 2025
  • Revision received October 5, 2025
  • Accepted October 6, 2025
  • Published online December 1, 2025.
Copyright & Usage 
Copyright © 2025 María-Ríos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Cristina E. María-Ríos1,
  2. Geoffrey G. Murphy1,2,3 and
  3. Jonathan D. Morrow1,2,4
  1. 1Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48109
  2. 2Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109
  3. 3Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109
  4. 4Psychiatry, University of Michigan, Ann Arbor, Michigan 48109
  1. Correspondence should be addressed to Jonathan D. Morrow at jonmorro{at}med.umich.edu or Geoffrey G. Murphy at murphyg{at}umich.edu.
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Author contributions

  1. Author contributions: C.E.M-R., G.G.M., and J.D.M. designed research; C.E.M-R. performed research; C.E.M-R. analyzed data; C.E.M-R., G.G.M., and J.D.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Science Foundation Graduate Research Fellowship Program (C.E.M.-R.), the National Institute of Neurological Disorders and Stroke (F99 NS120544, to C.E.M.-R.), the National Institute on Drug Abuse (K08 DA037912, to J.D.M.; R01 DA044960, to J.D.M.), the Taubman Emerging Scholar Fund (G022581, to J.D.M.), the Kenneth and Frances Eisenberg Award (G021877, to J.D.M.), the National Institute on Aging (R01 AG074552, to G.G.M.; R01 AG052934, to G.G.M.), and the National Institute of Mental Health (U19 MH106434, to G.G.M.).

Funding

  • National Science Foundation (NSF)

    Graduate Research Fellowship Program
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    F99 NS120544
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    K08 DA037912; R01 DA044960
  • Taubman Emerging Scholar Fund

    G022581
  • Kenneth and Frances Eisenberg Award

    G021877
  • HHS | NIH | National Institute on Aging (NIA)

    R01 AG074552; R01 AG052934
  • HHS | NIH | National Institute of Mental Health (NIMH)

    U19 MH106434

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Individual Variation in Intrinsic Neuronal Properties of Nucleus Accumbens Core and Shell Medium Spiny Neurons in Male Rats Prone to Sign- or Goal-Track
Cristina E. María-Ríos, Geoffrey G. Murphy, Jonathan D. Morrow
eNeuro 1 December 2025, 12 (12) ENEURO.0203-25.2025; DOI: 10.1523/ENEURO.0203-25.2025

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Individual Variation in Intrinsic Neuronal Properties of Nucleus Accumbens Core and Shell Medium Spiny Neurons in Male Rats Prone to Sign- or Goal-Track
Cristina E. María-Ríos, Geoffrey G. Murphy, Jonathan D. Morrow
eNeuro 1 December 2025, 12 (12) ENEURO.0203-25.2025; DOI: 10.1523/ENEURO.0203-25.2025
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Keywords

  • electrophysiology
  • incentive salience
  • individual differences
  • intrinsic excitability
  • pavlovian conditioning
  • ventral striatum

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