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Research ArticleResearch Article: Confirmation, Cognition and Behavior

Altered Dopamine Signaling in Extinction-Deficient Mice

Ozge Gunduz-Cinar, Eva Maria Fritz, Maya Xia, Elise Van Leer, Nevin Crow, Andrew Holmes and Nicolas Singewald
eNeuro 20 November 2025, 12 (11) ENEURO.0174-25.2025; https://doi.org/10.1523/ENEURO.0174-25.2025
Ozge Gunduz-Cinar
1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
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  • ORCID record for Ozge Gunduz-Cinar
Eva Maria Fritz
2Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck 6020, Austria
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Maya Xia
1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
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Elise Van Leer
1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
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Nevin Crow
1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
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Andrew Holmes
1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
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Nicolas Singewald
2Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck 6020, Austria
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0174-25.2025
PubMed 
41266139
Published By 
Society for Neuroscience
History 
  • Received March 28, 2025
  • Revision received August 27, 2025
  • Accepted September 12, 2025
  • Published online November 20, 2025.
Copyright & Usage 
Copyright © 2025 Gunduz-Cinar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ozge Gunduz-Cinar1,*,
  2. Eva Maria Fritz2,*,
  3. Maya Xia1,
  4. Elise Van Leer1,
  5. Nevin Crow1,
  6. Andrew Holmes1 and
  7. Nicolas Singewald2
  1. 1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20852
  2. 2Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck 6020, Austria
  1. Correspondence should be addressed to Ozge Gunduz-Cinar at gunduzcinaro{at}nih.gov.
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Author contributions

  1. Author contributions: O.G.-C., E.M.F., A.H., and N.S. designed research; O.G.-C., E.M.F., M.X., E.V.L., and N.C. performed research; A.H. and N.S. contributed unpublished reagents/analytic tools; O.G.-C., E.M.F., and M.X. analyzed data; O.G.-C., E.M.F., and A.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by the National Institute on Alcohol Abuse and Alcoholism Intramural Research Program and Austrian Science Fund (FWF, I2433-B26 and DKW-1206-B18).

  • ↵*O.G.-C. and E.M.F. contributed equally to this work.

Funding

  • HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  • Austrian Science Fund (FWF)

    I2433-B26 and DKW-1206-B18

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Altered Dopamine Signaling in Extinction-Deficient Mice
Ozge Gunduz-Cinar, Eva Maria Fritz, Maya Xia, Elise Van Leer, Nevin Crow, Andrew Holmes, Nicolas Singewald
eNeuro 20 November 2025, 12 (11) ENEURO.0174-25.2025; DOI: 10.1523/ENEURO.0174-25.2025

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Altered Dopamine Signaling in Extinction-Deficient Mice
Ozge Gunduz-Cinar, Eva Maria Fritz, Maya Xia, Elise Van Leer, Nevin Crow, Andrew Holmes, Nicolas Singewald
eNeuro 20 November 2025, 12 (11) ENEURO.0174-25.2025; DOI: 10.1523/ENEURO.0174-25.2025
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Keywords

  • DAT-Cre
  • dopamine
  • fear extinction
  • prediction error

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