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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease

Erzsebet M. Szatmari, Corey Moran, Sarah J. Cohen, Denys Bashtovyy, Amanda Jacob, Wyatt Bunner, Mary Phipps, Joan Cristino Lora, Robert W. Stackman and Ryohei Yasuda
eNeuro 17 November 2025, 12 (11) ENEURO.0063-25.2025; https://doi.org/10.1523/ENEURO.0063-25.2025
Erzsebet M. Szatmari
1Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458
2Department of Physical Therapy, East Carolina University, Greenville, North Carolina 27834
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Corey Moran
1Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458
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Sarah J. Cohen
3Florida Atlantic University, John D. McArthur Campus, Jupiter, Florida 33458
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Denys Bashtovyy
2Department of Physical Therapy, East Carolina University, Greenville, North Carolina 27834
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Amanda Jacob
1Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458
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Wyatt Bunner
2Department of Physical Therapy, East Carolina University, Greenville, North Carolina 27834
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Mary Phipps
2Department of Physical Therapy, East Carolina University, Greenville, North Carolina 27834
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Joan Cristino Lora
3Florida Atlantic University, John D. McArthur Campus, Jupiter, Florida 33458
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Robert W. Stackman
3Florida Atlantic University, John D. McArthur Campus, Jupiter, Florida 33458
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Ryohei Yasuda
1Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0063-25.2025
PubMed 
41249052
Published By 
Society for Neuroscience
History 
  • Received February 5, 2025
  • Revision received November 5, 2025
  • Accepted November 7, 2025
  • Published online November 17, 2025.
Copyright & Usage 
Copyright © 2025 Szatmari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Erzsebet M. Szatmari1,2,
  2. Corey Moran1,
  3. Sarah J. Cohen3,
  4. Denys Bashtovyy2,
  5. Amanda Jacob1,
  6. Wyatt Bunner2,
  7. Mary Phipps2,
  8. Joan Cristino Lora3,
  9. Robert W. Stackman3 and
  10. Ryohei Yasuda1
  1. 1Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458
  2. 2Department of Physical Therapy, East Carolina University, Greenville, North Carolina 27834
  3. 3Florida Atlantic University, John D. McArthur Campus, Jupiter, Florida 33458
  1. Correspondence should be addressed to Erzsebet M. Szatmari at szatmarie18{at}ecu.edu or Ryohei Yasuda at ryohei.yasuda{at}mpfi.org.
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Author contributions

  1. Author contributions: E.M.S., C.M., S.J.C., D.B., A.J., W.B., J.C.L., R.W.S., and R.Y. designed research; E.M.S., C.M., S.J.C., D.B., A.J., W.B., M.P., and J.C.L. performed research; E.M.S., C.M., S.J.C., D.B., A.J., W.B., M.P., J.C.L., R.W.S., and R.Y. analyzed data; E.M.S., S.J.C., D.B., and R.Y. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Minida Dowdy and the ARC at MPFI staff for their outstanding and compassionate animal care; Boram Yu (MPFI), Erin Suellentrop, and Elizabeth Brennan (ECU) for their technical support; Paramita Chakrabarty (University of Florida) for her expert advice on brain pathology analysis; and Yasuda, Stackman, and Szatmari lab members for their constructive discussions and review of the manuscript. This work was supported by the BrightFocus Foundation, Community Foundation of the Palm Beaches, NIA, Max Planck Foundation, ECU Startup funds, and ECU URCA awards.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    1R15NS125564-01
  • The Wooten Family Initiative for Brain Health Research

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Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
Erzsebet M. Szatmari, Corey Moran, Sarah J. Cohen, Denys Bashtovyy, Amanda Jacob, Wyatt Bunner, Mary Phipps, Joan Cristino Lora, Robert W. Stackman, Ryohei Yasuda
eNeuro 17 November 2025, 12 (11) ENEURO.0063-25.2025; DOI: 10.1523/ENEURO.0063-25.2025

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Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
Erzsebet M. Szatmari, Corey Moran, Sarah J. Cohen, Denys Bashtovyy, Amanda Jacob, Wyatt Bunner, Mary Phipps, Joan Cristino Lora, Robert W. Stackman, Ryohei Yasuda
eNeuro 17 November 2025, 12 (11) ENEURO.0063-25.2025; DOI: 10.1523/ENEURO.0063-25.2025
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Keywords

  • aging
  • Alzheimer's disease
  • dendritic spines
  • neuroinflammation
  • neuronal signaling
  • transcriptome

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