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Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons

Olivia J. Yang, Hannah B. Elam, Kayla Lilly, Alexandra M. McCoy, Valeriia Klepikova, Stephanie M. Perez and Daniel J. Lodge
eNeuro 7 October 2025, 12 (10) ENEURO.0222-25.2025; https://doi.org/10.1523/ENEURO.0222-25.2025
Olivia J. Yang
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Hannah B. Elam
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Kayla Lilly
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Alexandra M. McCoy
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Valeriia Klepikova
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Stephanie M. Perez
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
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Daniel J. Lodge
1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
2South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, Texas 78229
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0222-25.2025
PubMed 
41057264
Published By 
Society for Neuroscience
History 
  • Received June 7, 2025
  • Revision received June 25, 2025
  • Accepted September 12, 2025
  • Published online October 7, 2025.
Copyright & Usage 
Copyright © 2025 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Olivia J. Yang1,
  2. Hannah B. Elam1,
  3. Kayla Lilly1,
  4. Alexandra M. McCoy1,
  5. Valeriia Klepikova1,
  6. Stephanie M. Perez1 and
  7. Daniel J. Lodge1,2
  1. 1Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, Texas 78229
  2. 2South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, Texas 78229
  1. Correspondence should be addressed to Olivia J. Yang at yango{at}livemail.uthscsa.edu.
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Author contributions

  1. Author contributions: O.J.Y., S.M.P., and D.J.L. designed research; O.J.Y., H.B.E., K.L., A.M.M., and V.K. performed research; O.J.Y. and H.B.E. analyzed data; O.J.Y. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Dr. David Morilak for his thoughtful discussions on the topic that inspired the conceptualization of this work. This work was supported by Merit Awards #BX004693 and #BX004646 from the United States Department of Veterans Affairs, Biomedical Laboratory Research and Development Service (to D.J.L.), the National Institutes of Health R01-AG076030 (to S.M.P.), T32-NS082145 (to O.J.Y., H.B.E., K.L., and A.M.M.), and F31-MH127890-01A1 to H.B.E.

Funding

  • U.S. Department of Veterans Affairs (VA)

    #BX004693; #BX004646
  • HHS | National Institutes of Health (NIH)

    T32-NS082145
  • HHS | NIH | National Institute of Mental Health (NIMH)

    F31-MH127890-01A1

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The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons
Olivia J. Yang, Hannah B. Elam, Kayla Lilly, Alexandra M. McCoy, Valeriia Klepikova, Stephanie M. Perez, Daniel J. Lodge
eNeuro 7 October 2025, 12 (10) ENEURO.0222-25.2025; DOI: 10.1523/ENEURO.0222-25.2025

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The Ventral Pallidum Innervates a Distinct Subset of Midbrain Dopamine Neurons
Olivia J. Yang, Hannah B. Elam, Kayla Lilly, Alexandra M. McCoy, Valeriia Klepikova, Stephanie M. Perez, Daniel J. Lodge
eNeuro 7 October 2025, 12 (10) ENEURO.0222-25.2025; DOI: 10.1523/ENEURO.0222-25.2025
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Keywords

  • dopamine
  • psychiatric disorders
  • schizophrenia
  • ventral pallidum

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