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Research ArticleResearch Article: New Research, Integrative Systems

Frazzled/DCC Regulates Gap Junction Formation at a Drosophila Giant Synapse

Juan Lopez, Jana Boerner, Kelli Robbins, Rodrigo F. O. Pena and Rodney Murphey
eNeuro 8 October 2025, 12 (10) ENEURO.0202-25.2025; https://doi.org/10.1523/ENEURO.0202-25.2025
Juan Lopez
1Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida 33458
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Jana Boerner
2Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, Florida 33458
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Kelli Robbins
1Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida 33458
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Rodrigo F. O. Pena
1Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida 33458
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Rodney Murphey
1Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida 33458
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0202-25.2025
PubMed 
41062273
Published By 
Society for Neuroscience
History 
  • Received May 21, 2025
  • Revision received August 22, 2025
  • Accepted September 24, 2025
  • Published online October 8, 2025.
Copyright & Usage 
Copyright © 2025 Lopez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Juan Lopez1,
  2. Jana Boerner2,
  3. Kelli Robbins1,
  4. Rodrigo F. O. Pena1 and
  5. Rodney Murphey1
  1. 1Department of Biological Sciences, Florida Atlantic University, Jupiter, Florida 33458
  2. 2Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, Florida 33458
  1. Correspondence should be addressed to Rodney Murphey at rmurphey{at}fau.edu.
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Author contributions

  1. Author contributions: J.L., K.R., R.F.O.P., and R.M. designed research; J.L. and J.B. performed research; J.L., J.B., and K.R. contributed unpublished reagents/analytic tools; J.L. and R.F.O.P. analyzed data; J.L. and R.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Dr. Greg Bashaw for his fly lines used in the work. This work was supported by grants from the Jupiter Life Science Initiative.

Funding

  • Jupiter Life Science Initiative

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  • previous version (October 08, 2025).

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eneuro: 12 (10)
eNeuro
Vol. 12, Issue 10
October 2025
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Frazzled/DCC Regulates Gap Junction Formation at a Drosophila Giant Synapse
Juan Lopez, Jana Boerner, Kelli Robbins, Rodrigo F. O. Pena, Rodney Murphey
eNeuro 8 October 2025, 12 (10) ENEURO.0202-25.2025; DOI: 10.1523/ENEURO.0202-25.2025

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Frazzled/DCC Regulates Gap Junction Formation at a Drosophila Giant Synapse
Juan Lopez, Jana Boerner, Kelli Robbins, Rodrigo F. O. Pena, Rodney Murphey
eNeuro 8 October 2025, 12 (10) ENEURO.0202-25.2025; DOI: 10.1523/ENEURO.0202-25.2025
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Keywords

  • computational
  • Drosophila
  • Frazzled/DCC
  • gap junction
  • Giant Fiber
  • synapse

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