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Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods

Dynamotypes for Dummies: A Toolbox, Atlas, and Tutorial for Simulating a Comprehensive Range of Realistic Synthetic Seizures

Christina Sheckler, Kathleen Kish, Zion Walker, Grant Barkelew, Dakota N. Crisp, Matt P. Szuromi, Maria Luisa Saggio and William C. Stacey
eNeuro 30 September 2025, 12 (10) ENEURO.0200-25.2025; https://doi.org/10.1523/ENEURO.0200-25.2025
Christina Sheckler
1Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109
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Kathleen Kish
1Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109
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Zion Walker
2Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109
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Grant Barkelew
1Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109
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Dakota N. Crisp
2Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109
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Matt P. Szuromi
3Department of Mathematics and Statistics, Graduate Program for Neurosciences, Boston University, Boston, Massachusetts 02215
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Maria Luisa Saggio
4Aix Marseille Univ, INSERM, INS, Marseille 13284, France
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  • ORCID record for Maria Luisa Saggio
William C. Stacey
1Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109
2Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109
5VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0200-25.2025
PubMed 
41027733
Published By 
Society for Neuroscience
History 
  • Received May 17, 2025
  • Revision received September 18, 2025
  • Accepted September 22, 2025
  • Published online September 30, 2025.
Copyright & Usage 
Copyright © 2025 Sheckler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christina Sheckler1,*,
  2. Kathleen Kish1,*,
  3. Zion Walker2,
  4. Grant Barkelew1,
  5. Dakota N. Crisp2,
  6. Matt P. Szuromi3,
  7. Maria Luisa Saggio4 and
  8. William C. Stacey1,2,5
  1. 1Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109
  2. 2Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109
  3. 3Department of Mathematics and Statistics, Graduate Program for Neurosciences, Boston University, Boston, Massachusetts 02215
  4. 4Aix Marseille Univ, INSERM, INS, Marseille 13284, France
  5. 5VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105
  1. Correspondence should be addressed to William Stacey at william.stacey{at}umich.edu.
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Author contributions

  1. Author contributions: C.S., K.K., D.N.C., M.P.S., M.L.S., and W.C.S. designed research; C.S., K.K., Z.W., G.B., D.N.C., M.P.S., and W.C.S. performed research; C.S., K.K., M.P.S., M.L.S., and W.C.S. analyzed data; C.S., K.K., M.P.S., M.L.S., and W.C.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by NIH (R01-NS094399 to W.S. and K12-GM111725 to K.K.), Michigan Medicine: Robbins Family Fund and Lucas Family Fund (C.S., Z.W., D.N.C., M.P.S.), University of Michigan: BioInterfaces Institute (W.S., C.S., Z.W., G.B.), EBS Innovation Initiative (D.N.C), and EU Horizon Europe (101147319; M.L.S.).

  • ↵*C.S. and K.K. contributed equally to this work.

Funding

  • HHS | National Institutes of Health (NIH)

    R01-NS094399; K12-GM111725
  • U-M | Michigan Medicine, University of Michigan (MM)

    Robbins Family Fund; Lucas Family Fund
  • U-M | Biointerfaces Institute, University of Michigan (BI)

  • University of Michigan (U-M)

    EBS Innovation Initiative
  • EU Horizon Europe

    101147319

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Dynamotypes for Dummies: A Toolbox, Atlas, and Tutorial for Simulating a Comprehensive Range of Realistic Synthetic Seizures
Christina Sheckler, Kathleen Kish, Zion Walker, Grant Barkelew, Dakota N. Crisp, Matt P. Szuromi, Maria Luisa Saggio, William C. Stacey
eNeuro 30 September 2025, 12 (10) ENEURO.0200-25.2025; DOI: 10.1523/ENEURO.0200-25.2025

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Dynamotypes for Dummies: A Toolbox, Atlas, and Tutorial for Simulating a Comprehensive Range of Realistic Synthetic Seizures
Christina Sheckler, Kathleen Kish, Zion Walker, Grant Barkelew, Dakota N. Crisp, Matt P. Szuromi, Maria Luisa Saggio, William C. Stacey
eNeuro 30 September 2025, 12 (10) ENEURO.0200-25.2025; DOI: 10.1523/ENEURO.0200-25.2025
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Keywords

  • bifurcation
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  • epilepsy
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