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Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods

Optical Assay of the Functional Impact of Cuprizone-Induced Demyelination and Remyelination on Interhemispheric Neural Communication in the Anterior Cingulate Cortex via the Corpus Callosum

Kyoka Tsukuda, Yoko Tominaga, Makiko Taketoshi, Michiko Miwa, Kentaro Nakashima and Takashi Tominaga
eNeuro 2 January 2025, 12 (1) ENEURO.0511-24.2024; https://doi.org/10.1523/ENEURO.0511-24.2024
Kyoka Tsukuda
1Graduate School of Pharmaceutical Science, Tokushima Bunri University, Sanuki 769-2193, Japan
2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
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Yoko Tominaga
2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
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Makiko Taketoshi
2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
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Michiko Miwa
3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Japan
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Kentaro Nakashima
1Graduate School of Pharmaceutical Science, Tokushima Bunri University, Sanuki 769-2193, Japan
2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Japan
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Takashi Tominaga
1Graduate School of Pharmaceutical Science, Tokushima Bunri University, Sanuki 769-2193, Japan
2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0511-24.2024
PubMed 
39746809
Published By 
Society for Neuroscience
History 
  • Received November 8, 2024
  • Revision received December 2, 2024
  • Accepted December 7, 2024
  • Published online January 2, 2025.
Copyright & Usage 
Copyright © 2025 Tsukuda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kyoka Tsukuda1,2,
  2. Yoko Tominaga2,
  3. Makiko Taketoshi2,
  4. Michiko Miwa3,
  5. Kentaro Nakashima1,2,3 and
  6. Takashi Tominaga1,2,3
  1. 1Graduate School of Pharmaceutical Science, Tokushima Bunri University, Sanuki 769-2193, Japan
  2. 2Institute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Japan
  3. 3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Japan
  1. Correspondence should be addressed to Takashi Tominaga at tominagat{at}kph.bunri-u.ac.jp.
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Author contributions

  1. Author contributions: K.T., Y.T., K.N., and T.T. designed research; K.T., Y.T., M.T., M.M., K.N., and T.T. performed research; K.T., Y.T., K.N., and T.T. contributed unpublished reagents/analytic tools; K.T., Y.T., K.N., and T.T. analyzed data; K.T., Y.T., and T.T. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Ms. Ai Taniguchi for her invaluable technical assistance with animal care. This work was supported by Japan Society for the Promotion of Science Grant JP24H01497, JP24K03085, JP24K22259, JP23K21755, JP23K18485, JP22H05698, JP21H03606, JP21K06702, JP21H03532, JP21H00447, JP20H04341, JP19H01142, and JP16H06532 to T.T. and JP24K18267 and JP21K15247 to Y.T.

Funding

  • MEXT | Japan Society for the Promotion of Science (JSPS)

    JP24H01497; JP24K03085; JP24K22259; JP23K21755; JP23K18485; JP22H05698; JP21H03606; JP21K06702; JP21H03532; JP21H00447; JP20H04341; JP19H01142; JP16H06532; JP24K18267; JP21K15247

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Jan 2025312443175
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Optical Assay of the Functional Impact of Cuprizone-Induced Demyelination and Remyelination on Interhemispheric Neural Communication in the Anterior Cingulate Cortex via the Corpus Callosum
Kyoka Tsukuda, Yoko Tominaga, Makiko Taketoshi, Michiko Miwa, Kentaro Nakashima, Takashi Tominaga
eNeuro 2 January 2025, 12 (1) ENEURO.0511-24.2024; DOI: 10.1523/ENEURO.0511-24.2024

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Optical Assay of the Functional Impact of Cuprizone-Induced Demyelination and Remyelination on Interhemispheric Neural Communication in the Anterior Cingulate Cortex via the Corpus Callosum
Kyoka Tsukuda, Yoko Tominaga, Makiko Taketoshi, Michiko Miwa, Kentaro Nakashima, Takashi Tominaga
eNeuro 2 January 2025, 12 (1) ENEURO.0511-24.2024; DOI: 10.1523/ENEURO.0511-24.2024
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Keywords

  • anterior cingulate cortex
  • corpus callosum
  • cuprizone
  • medial prefrontal cortex
  • multiple sclerosis
  • voltage-sensitive dye

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