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Research ArticleResearch Article: New Research, Integrative Systems

The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report

Simone Ciceri, Matthijs N. Oude Lohuis, Vivi Rottschäfer, Cyriel M. A. Pennartz, Daniele Avitabile, Simon van Gaal and Umberto Olcese
eNeuro 11 September 2024, 11 (9) ENEURO.0191-24.2024; https://doi.org/10.1523/ENEURO.0191-24.2024
Simone Ciceri
1Institute for Theoretical Physics, Utrecht University, Utrecht 3584CC, Netherlands
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Matthijs N. Oude Lohuis
2Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
3Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
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  • ORCID record for Matthijs N. Oude Lohuis
Vivi Rottschäfer
4Mathematical Institute, Leiden University, Leiden 2333CA, Netherlands
5Korteweg-de Vries Institute for Mathematics, University of Amsterdam, Amsterdam 1098XG, Netherlands
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Cyriel M. A. Pennartz
2Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
3Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
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Daniele Avitabile
6Amsterdam Center for Dynamics and Computation, Mathematics Department, Vrije Universiteit Amsterdam, Amsterdam 1081HV, Netherlands
7Mathneuro Team, Inria Centre at Université Côte d’Azur, Sophia Antipolis 06902, France
8Amsterdam Neuroscience, Systems and Network Neuroscience, Amsterdam 1081HV, Netherlands
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Simon van Gaal
3Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
9Department of Psychology, University of Amsterdam, Amsterdam 1018WT, Netherlands
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Umberto Olcese
2Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
3Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0191-24.2024
PubMed 
39260892
Published By 
Society for Neuroscience
History 
  • Received May 1, 2024
  • Revision received July 9, 2024
  • Accepted July 12, 2024
  • Published online September 11, 2024.
Copyright & Usage 
Copyright © 2024 Ciceri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Simone Ciceri1,
  2. Matthijs N. Oude Lohuis2,3,
  3. Vivi Rottschäfer4,5,
  4. Cyriel M. A. Pennartz2,3,
  5. Daniele Avitabile6,7,8,*,
  6. Simon van Gaal3,9,* and
  7. Umberto Olcese2,3,*
  1. 1Institute for Theoretical Physics, Utrecht University, Utrecht 3584CC, Netherlands
  2. 2Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam 1098XH, Netherlands
  3. 3Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam 1098XH, Netherlands
  4. 4Mathematical Institute, Leiden University, Leiden 2333CA, Netherlands
  5. 5Korteweg-de Vries Institute for Mathematics, University of Amsterdam, Amsterdam 1098XG, Netherlands
  6. 6Amsterdam Center for Dynamics and Computation, Mathematics Department, Vrije Universiteit Amsterdam, Amsterdam 1081HV, Netherlands
  7. 7Mathneuro Team, Inria Centre at Université Côte d’Azur, Sophia Antipolis 06902, France
  8. 8Amsterdam Neuroscience, Systems and Network Neuroscience, Amsterdam 1081HV, Netherlands
  9. 9Department of Psychology, University of Amsterdam, Amsterdam 1018WT, Netherlands
  1. Correspondence should be addressed to Daniele Avitabile at d.avitabile{at}vu.nl, Simon van Gaal at s.vangaal{at}uva.nl, or Umberto Olcese at u.olcese{at}uva.nl.
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Author contributions

  1. Author contributions: V.R., C.M.A.P., D.A., S.V.G., and U.O. designed research; S.C., M.N.O.L., D.A., and U.O. performed research; S.C., D.A., and U.O. analyzed data; S.C., V.R., D.A., S.V.G., and U.O. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Eric Dijkema for providing support in accessing the data used for Figure 1 and the Carandini/Harris lab for providing free access to the raw data used in Steinmetz et al. (2019). We also thank the Institute for Advanced Studies of the University of Amsterdam for supporting a workshop that spearheaded this study. This work was supported by Netherlands Organization for Scientific Research (NWO Crossover project INTENSE to U.O. and C.M.A.P.) and the European Research Council (ERC Starting grant, 715605 project CONSCIOUSNESS to S.V.G.). This project was also made possible through the support of a grant from Templeton World Charity Foundation, Inc. (funder DOI 501100011730) through grants TWCF0646 (to U.O. and C.M.A.P.) and TWCF-2022-30261 (to U.O.). The opinions expressed in this publication are those of the authors and do not necessarily reflect the views of Templeton World Charity Foundation, Inc.

  • ↵*D.A., S.G., and U.O. contributed equally to this work.

  • M.N.O.L.’s present address: Champalimaud Research, Champalimaud Foundation, Lisbon 1400-038, Portugal

Funding

  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)

    Crossover project INTENSE
  • EC | ERC | HORIZON EUROPE European Research Council (ERC)

    715605
  • Templeton World Charity Foundation (TWCF)

    TWCF0646; TWCF-2022-30261

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The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report
Simone Ciceri, Matthijs N. Oude Lohuis, Vivi Rottschäfer, Cyriel M. A. Pennartz, Daniele Avitabile, Simon van Gaal, Umberto Olcese
eNeuro 11 September 2024, 11 (9) ENEURO.0191-24.2024; DOI: 10.1523/ENEURO.0191-24.2024

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The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report
Simone Ciceri, Matthijs N. Oude Lohuis, Vivi Rottschäfer, Cyriel M. A. Pennartz, Daniele Avitabile, Simon van Gaal, Umberto Olcese
eNeuro 11 September 2024, 11 (9) ENEURO.0191-24.2024; DOI: 10.1523/ENEURO.0191-24.2024
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Keywords

  • computational neuroscience
  • consciousness
  • perception
  • report-related activity

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