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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Not a Deficit, Just Different: Prepulse Inhibition Disruptions in Autism Depend on Startle Stimulus Intensities

Ella Elizabeth Doornaert, Alaa El-Cheikh Mohamad, Gurwinder Johal, Brian Leonard Allman, Dorit Möhrle and Susanne Schmid
eNeuro 19 August 2024, 11 (9) ENEURO.0179-24.2024; https://doi.org/10.1523/ENEURO.0179-24.2024
Ella Elizabeth Doornaert
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Alaa El-Cheikh Mohamad
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Gurwinder Johal
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Brian Leonard Allman
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Dorit Möhrle
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
2Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
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Susanne Schmid
1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
3Psychology, University of Western Ontario, London, Ontario N6A 5C1, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0179-24.2024
PubMed 
39160071
Published By 
Society for Neuroscience
History 
  • Received April 26, 2024
  • Revision received August 8, 2024
  • Accepted August 14, 2024
  • Published online August 19, 2024.
Copyright & Usage 
Copyright © 2024 Doornaert et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ella Elizabeth Doornaert1,
  2. Alaa El-Cheikh Mohamad1,
  3. Gurwinder Johal1,
  4. Brian Leonard Allman1,
  5. Dorit Möhrle1,2,* and
  6. Susanne Schmid1,3,*
  1. 1Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
  2. 2Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
  3. 3Psychology, University of Western Ontario, London, Ontario N6A 5C1, Canada
  1. Correspondence should be addressed to Susanne Schmid at susanne.schmid{at}schulich.uwo.ca.
View Full Text

Author contributions

  1. Author contributions: B.L.A., D.M., and S.S. designed research; E.E.D. and G.J. performed research; A.E.-C.M., D.M., and S.S. contributed unpublished reagents/analytic tools; E.E.D. and D.M. analyzed data; E.E.D. and S.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants to S.S. from the Canadian Institute for Health Sciences (CIHR, PJF168866) and the Natural Science and Engineering Council (NSERC, 044722018RGPIN), a Fellowship of the Deutsche Forschungsgemeinschaft for D.M. (DFG, 442662585), and a C. Kingsley Allison Research Grant by the University of Western Ontario to D.M. E.E.D. was funded by a Natural Sciences and Engineering Research Council of Canada Undergraduate Student’s Research Award (NSERC USRA).

  • ↵*D.M. and S.S. share co-senior authorship.

Funding

  • Canadian Government | Canadian Institutes of Health Research (CIHR)

    PJF168866
  • Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)

    044722018RGPIN; NSERC-USRA
  • Deutsche Forschungsgemeinschaft (DFG)

    442662585

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  • You are viewing the most recent version of this article.
  • previous version (August 19, 2024).

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Not a Deficit, Just Different: Prepulse Inhibition Disruptions in Autism Depend on Startle Stimulus Intensities
Ella Elizabeth Doornaert, Alaa El-Cheikh Mohamad, Gurwinder Johal, Brian Leonard Allman, Dorit Möhrle, Susanne Schmid
eNeuro 19 August 2024, 11 (9) ENEURO.0179-24.2024; DOI: 10.1523/ENEURO.0179-24.2024

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Not a Deficit, Just Different: Prepulse Inhibition Disruptions in Autism Depend on Startle Stimulus Intensities
Ella Elizabeth Doornaert, Alaa El-Cheikh Mohamad, Gurwinder Johal, Brian Leonard Allman, Dorit Möhrle, Susanne Schmid
eNeuro 19 August 2024, 11 (9) ENEURO.0179-24.2024; DOI: 10.1523/ENEURO.0179-24.2024
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Keywords

  • animal model
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