Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Commentary, Disorders of the Nervous System

What's in It for Me? Contextualizing the Potential Clinical Impacts of Lecanemab, Donanemab, and Other Anti-β-amyloid Monoclonal Antibodies in Early Alzheimer's Disease

Michelle Jin and James M. Noble
eNeuro 27 September 2024, 11 (9) ENEURO.0088-24.2024; https://doi.org/10.1523/ENEURO.0088-24.2024
Michelle Jin
1Medical Scientist Training Program (MSTP), Columbia University Irving Medical Center (CUIMC), New York, New York 10032
2Neurobiology and Behavior (NB&B) Graduate Program, Columbia University, New York, New York 10027
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michelle Jin
James M. Noble
3Department of Neurology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, and the GH Sergievsky Center, Columbia University Irving Medical Center, New York, New York 10032
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0088-24.2024
PubMed 
39332901
Published By 
Society for Neuroscience
History 
  • Received February 26, 2024
  • Revision received September 3, 2024
  • Accepted September 9, 2024
  • Published online September 27, 2024.
Copyright & Usage 
Copyright © 2024 Jin and Noble This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Michelle Jin1,2 and
  2. James M. Noble3
  1. 1Medical Scientist Training Program (MSTP), Columbia University Irving Medical Center (CUIMC), New York, New York 10032
  2. 2Neurobiology and Behavior (NB&B) Graduate Program, Columbia University, New York, New York 10027
  3. 3Department of Neurology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, and the GH Sergievsky Center, Columbia University Irving Medical Center, New York, New York 10032
  1. Correspondence should be addressed to Michelle Jin at mj2947{at}cumc.columbia.edu or James M. Noble at jn2054{at}columbia.edu.
View Full Text

Author contributions

  1. Author contributions: M.J. and J.M.N. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Dr. Christine Ann Denny for her constructive feedback on an initial draft of this manuscript. This work was supported by the National Institute of General Medical Sciences (T32GM007367 to M.J./Columbia MSTP) and by the National Institute on Aging (F30AG084312 to M.J.).

Funding

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    T32GM007367
  • HHS | NIH | National Institute on Aging (NIA)

    F30AG084312

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2026-04-21
to
E.g., 2026-04-21

Article usage: September 2024 to April 2026

AbstractFullPdf
Sep 202410828793
Oct 2024439830287
Nov 2024138389175
Dec 202498576245
Total 20247832082800
Jan 2025129324182
Feb 202562270140
Mar 202542296111
Apr 202574244110
May 20254227782
Jun 20253327966
Jul 202532268246
Aug 20254728983
Sep 202549395141
Oct 202539320108
Nov 202522443106
Dec 202529561116
Total 202560039661491
Jan 20263340782
Feb 20262835637
Mar 20263553966
Apr 20262516851
Total 20261211470236
Total150475182527
Back to top

In this issue

eneuro: 11 (9)
eNeuro
Vol. 11, Issue 9
September 2024
  • Table of Contents
  • Index by author
  • Masthead (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
What's in It for Me? Contextualizing the Potential Clinical Impacts of Lecanemab, Donanemab, and Other Anti-β-amyloid Monoclonal Antibodies in Early Alzheimer's Disease
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
What's in It for Me? Contextualizing the Potential Clinical Impacts of Lecanemab, Donanemab, and Other Anti-β-amyloid Monoclonal Antibodies in Early Alzheimer's Disease
Michelle Jin, James M. Noble
eNeuro 27 September 2024, 11 (9) ENEURO.0088-24.2024; DOI: 10.1523/ENEURO.0088-24.2024

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
What's in It for Me? Contextualizing the Potential Clinical Impacts of Lecanemab, Donanemab, and Other Anti-β-amyloid Monoclonal Antibodies in Early Alzheimer's Disease
Michelle Jin, James M. Noble
eNeuro 27 September 2024, 11 (9) ENEURO.0088-24.2024; DOI: 10.1523/ENEURO.0088-24.2024
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Conclusions
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • Alzheimer’s disease
  • clinical efficacy
  • donanemab
  • lecanemab
  • minimal clinically important difference

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Commentary

  • Learning Environments and Brain Health: A Neuroeducational Perspective
  • What Is My Neuron Doing? Commentary on Huang et al. (2026)
  • Experimental Designs for Preclinical Neuroscience Experiments: Part 2—Blocking and Blocked Designs
Show more Commentary

Disorders of the Nervous System

  • A Multi-Network Approach Identifies Proteins Related to Dendritic Spines in Alzheimer’s Disease
  • Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure
  • Parvalbumin Neuron–Targeted Loss of Alzheimer’s Disease Risk Gene BIN1 Is Insufficient to Drive Cognitive or Network Excitability Changes
Show more Disorders of the Nervous System

Subjects

  • Brain Mysteries: Complexity Beyond Imagination
  • Disorders of the Nervous System
  • Commentaries
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2026 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.