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Research ArticleResearch Article: New Research, Cognition and Behavior

Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges

Manal S. Abdelaal, Tomonobu Kato, Akiyo Natsubori and Kenji F. Tanaka
eNeuro 10 September 2024, 11 (9) ENEURO.0058-24.2024; https://doi.org/10.1523/ENEURO.0058-24.2024
Manal S. Abdelaal
1Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
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Tomonobu Kato
1Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
2Department of System Design Engineering, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
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Akiyo Natsubori
3Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-Ku, Tokyo 156-8506, Japan
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Kenji F. Tanaka
1Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0058-24.2024
PubMed 
39256042
Published By 
Society for Neuroscience
History 
  • Received January 16, 2024
  • Revision received August 27, 2024
  • Accepted August 29, 2024
  • Published online September 10, 2024.
Copyright & Usage 
Copyright © 2024 Abdelaal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Manal S. Abdelaal1,
  2. Tomonobu Kato1,2,
  3. Akiyo Natsubori3 and
  4. Kenji F. Tanaka1
  1. 1Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
  2. 2Department of System Design Engineering, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
  3. 3Sleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-Ku, Tokyo 156-8506, Japan
  1. Correspondence should be addressed to Manal S. Abdelaal at manal.abdelaal{at}keio.jp.
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Author contributions

  1. Author contributions: M.S.A., T.K., and K.F.T. designed research; M.S.A. and T.K. performed research; M.S.A. contributed unpublished reagents/analytic tools; M.S.A. and T.K. analyzed data; M.S.A., A.N., and K.F.T. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Dr. Norio Takata for helpful comments on this manuscript. We would like to thank Editage (www.editage.com) for English language editing. This research was supported by a grant from Brain Mapping by Integrated Neurotechnologies for Disease Studies (brain/MINDS) by the Agency for Medical Research and Development (AMED), Japan, under Grant JP22dmo0207069 (to K.F.T.).

Funding

  • Japan Agency for Medical Research and Development (AMED)

    JP22dmo0207069

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eneuro: 11 (9)
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September 2024
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Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges
Manal S. Abdelaal, Tomonobu Kato, Akiyo Natsubori, Kenji F. Tanaka
eNeuro 10 September 2024, 11 (9) ENEURO.0058-24.2024; DOI: 10.1523/ENEURO.0058-24.2024

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Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges
Manal S. Abdelaal, Tomonobu Kato, Akiyo Natsubori, Kenji F. Tanaka
eNeuro 10 September 2024, 11 (9) ENEURO.0058-24.2024; DOI: 10.1523/ENEURO.0058-24.2024
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Keywords

  • absence seizures
  • cortico–thalamo–cortical network
  • electroencephalographic
  • sleep
  • sleep spindles
  • spike-and-wave discharges
  • tTA-tetO system

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