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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3+/D801Y

Yi Bessie Liu, Elena Arystarkhova, Amanda N. Sacino, Margit V. Szabari, Cathleen M. Lutz, Markus Terrey, Natalia S. Morsci, Tatjana C. Jakobs, Karin Lykke-Hartmann, Allison Brashear, Elenora Napoli and Kathleen J. Sweadner
eNeuro 7 August 2024, 11 (8) ENEURO.0101-24.2024; https://doi.org/10.1523/ENEURO.0101-24.2024
Yi Bessie Liu
1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
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Elena Arystarkhova
1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
2Harvard Medical School, Boston, Massachusetts 02115
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Amanda N. Sacino
1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
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Margit V. Szabari
3Department Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02114
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Cathleen M. Lutz
4The Jackson Laboratory, Bar Harbor, Maine 04609
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Markus Terrey
4The Jackson Laboratory, Bar Harbor, Maine 04609
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Natalia S. Morsci
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Tatjana C. Jakobs
2Harvard Medical School, Boston, Massachusetts 02115
5Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114
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Karin Lykke-Hartmann
6Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark
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Allison Brashear
7Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
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Elenora Napoli
8Department of Neurology, University of California Davis School of Medicine, Sacramento, California 95817
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Kathleen J. Sweadner
1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
2Harvard Medical School, Boston, Massachusetts 02115
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0101-24.2024
PubMed 
39111836
Published By 
Society for Neuroscience
History 
  • Received March 8, 2024
  • Revision received July 24, 2024
  • Accepted July 25, 2024
  • Published online August 7, 2024.
Copyright & Usage 
Copyright © 2024 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yi Bessie Liu1,
  2. Elena Arystarkhova1,2,
  3. Amanda N. Sacino1,
  4. Margit V. Szabari3,
  5. Cathleen M. Lutz4,
  6. Markus Terrey4,
  7. Natalia S. Morsci,
  8. Tatjana C. Jakobs2,5,
  9. Karin Lykke-Hartmann6,
  10. Allison Brashear7,
  11. Elenora Napoli8 and
  12. Kathleen J. Sweadner1,2
  1. 1Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114
  2. 2Harvard Medical School, Boston, Massachusetts 02115
  3. 3Department Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02114
  4. 4The Jackson Laboratory, Bar Harbor, Maine 04609
  5. 5Department of Ophthalmology, Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114
  6. 6Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark
  7. 7Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203
  8. 8Department of Neurology, University of California Davis School of Medicine, Sacramento, California 95817
  1. Correspondence should be addressed to Kathleen J. Sweadner at ksweadner{at}mgh.harvard.edu.
View Full Text

Author contributions

  1. Author contributions: C.M.L., A.B., and K.J.S. designed research; Y.B.L., A.N.S., M.V.S., T.C.J., and K.J.S. performed research; K.L.-H. contributed unpublished reagents/analytic tools; Y.B.L., E.A., A.N.S., M.V.S., C.M.L., M.T., N.M., T.C.J., E.N., and K.J.S. analyzed data; E.N. and K.J.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health grants R01 NS058949, PI A.B.; R21 NS081558, PI K.J.S.; a grant from the Chan-Zuckerberg Initiative, PI David Liu; a grant from Hope for Annabel Foundation, PI K.J.S.; and a grant from Cure AHC Foundation, PI K.J.S.

Funding

  • NIH

    NS081558; NS058949
  • CureAHC Foundation

  • Hope for Annabel

  • Chan-Zuckerberg Initative

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 07, 2024).

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Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3+/D801Y
Yi Bessie Liu, Elena Arystarkhova, Amanda N. Sacino, Margit V. Szabari, Cathleen M. Lutz, Markus Terrey, Natalia S. Morsci, Tatjana C. Jakobs, Karin Lykke-Hartmann, Allison Brashear, Elenora Napoli, Kathleen J. Sweadner
eNeuro 7 August 2024, 11 (8) ENEURO.0101-24.2024; DOI: 10.1523/ENEURO.0101-24.2024

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Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3+/D801Y
Yi Bessie Liu, Elena Arystarkhova, Amanda N. Sacino, Margit V. Szabari, Cathleen M. Lutz, Markus Terrey, Natalia S. Morsci, Tatjana C. Jakobs, Karin Lykke-Hartmann, Allison Brashear, Elenora Napoli, Kathleen J. Sweadner
eNeuro 7 August 2024, 11 (8) ENEURO.0101-24.2024; DOI: 10.1523/ENEURO.0101-24.2024
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Keywords

  • ATP1A3
  • disease mutation
  • motor testing
  • mouse model
  • Na,K-ATPase

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