Article Information
- Received August 29, 2023
- Revision received May 17, 2024
- Accepted May 20, 2024
- Published online June 12, 2024.
Author Information
- Felicitas Bruentgens1,2,
- Laura Moreno Velasquez1,2,*,
- Alexander Stumpf1,2,*,
- Daniel Parthier1,2,3,
- Jörg Breustedt1,2,
- Fabio Benfenati4,5,
- Dragomir Milovanovic1,6,7,
- Dietmar Schmitz1,2,3,6,7,8 and
- Marta Orlando1,2
- 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany
- 2NeuroCure Cluster of Excellence, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin 10117, Germany
- 3Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany
- 4Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genoa 16163, Italy
- 5IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy
- 6German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin 10117, Germany
- 7Einstein Center for Neurosciences, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Berlin, Berlin 10117, Germany
- 8Bernstein Center for Computational Neuroscience, Humboldt-Universität zu Berlin, Berlin 10115, Germany
- Correspondence should be addressed to Marta Orlando at marta.orlando{at}charite.de or Dietmar Schmitz at dietmar.schmitz{at}charite.de.
Author contributions
Author contributions: D.S. and M.O. designed research; Felicitas Bruentgens, L.M.V., A.S., and M.O. performed research; Fabio Benfenati and D.M. contributed unpublished reagents/analytic tools; Felicitas Bruentgens, L.M.V., A.S., D.P., J.B. and M.O. analyzed data; Felicitas Bruentgens and M.O. wrote the paper.
Disclosures
The authors declare no competing financial interests.
This study was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project 184695641, SFB 958 (to D.S.); project 327654276, SFB 1315 (to D.S.); project 415914819, FOR 3004 (to D.S.); project 431572356 (to D.S.), under Germany's Excellence Strategy EXC-2049-390688087 (NeuroCure; to D.S. and M.O.); and project 503954250 (to M.O.). It was also supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (BrainPlay Grant Agreement No. 810580; to D.S.) and by the Federal Ministry of Education and Research (BMBF, SmartAge, Project 01GQ1420B; to D.S.). D.M. is supported by the startup funds from DZNE, the grants from the German Research Foundation (317475864; SFB 1286/B10 and MI 2104), and the Human Frontiers Science Organization (RGEC32/2023). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Susanne Rieckmann for her excellent technical assistance. We thank Anke Schönherr and Caterina Michetti for organizational matters with SynTKO animals as well as Christian Hoffmann and Franziska Trnka for their assistance in obtaining the necessary animal permits for the SynTKO line. We thank the Electron Microscopy Laboratory of the Institute of Integrative Neuroanatomy and the Core Facility for Electron Microscopy of the Charité for granting us access to their instruments. We thank René Bernard for his valuable input on Open Science. Finally, we thank Antje Fortströer for the careful revision of our manuscript.
↵*L.M.V. and A.S. contributed equally to this work.
Funding
Deutsche Forschungsgemeinschaft (DFG)
184695641; 327654276; 415914819; 431572356; EXC-2049-390688087; 503954250; 317475864EC | ERC | HORIZON EUROPE European Research Council (ERC)
810580Bundesministerium für Bildung und Forschung (BMBF)
01GQ1420BHuman Frontiers Science Organization
RGEC32/2023
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