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Commentary, Disorders of the Nervous System

Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data

Alberto J. Espay, Kasper P. Kepp and Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; https://doi.org/10.1523/ENEURO.0319-23.2024
Alberto J. Espay
1Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio 45219
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Kasper P. Kepp
2Section of Biophysical and Biomedicinal Chemistry, Department of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark
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Karl Herrup
3Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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    Figure 1.

    Comparison of the efficacy slopes and absolute changes for donepezil and lecanemab versus placebo. Improvement from the baseline was only observed for donepezil. In both cases, visual divergence in the curves suggested the possibility of greater benefits beyond the short window of the trials. Note the scale of Y axis is equal in both studies, facilitating comparison. IV, intravenous. ADAS-Cog, cognitive subscale of the Alzheimer's Disease Assessment Scale; range 0–90, higher means worse. The MCID for this scale is 3 points. Adapted from data in Rogers (1998) and van Dyck et al. (2023).

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    Figure 2.

    Infographic of the lecanemab pivotal trial. The data are shown to facilitate a comprehensive interpretation of the clinical trial data in the authors’ perspective.

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    Figure 3.

    Infographic of the donanemab pivotal trial. The data are shown to facilitate a comprehensive interpretation of the clinical trial data in the authors’ perspective.

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eneuro: 11 (7)
eNeuro
Vol. 11, Issue 7
July 2024
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Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
Alberto J. Espay, Kasper P. Kepp, Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; DOI: 10.1523/ENEURO.0319-23.2024

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Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
Alberto J. Espay, Kasper P. Kepp, Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; DOI: 10.1523/ENEURO.0319-23.2024
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Keywords

  • aducanumab
  • Alzheimer's disease
  • antiamyloid monoclonal antibodies
  • beta-amyloid
  • donanemab
  • lecanemab

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