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Commentary, Disorders of the Nervous System

Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data

Alberto J. Espay, Kasper P. Kepp and Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; https://doi.org/10.1523/ENEURO.0319-23.2024
Alberto J. Espay
1Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio 45219
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Kasper P. Kepp
2Section of Biophysical and Biomedicinal Chemistry, Department of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark
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Karl Herrup
3Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0319-23.2024
PubMed 
38951040
Published By 
Society for Neuroscience
History 
  • Received August 27, 2023
  • Revision received April 18, 2024
  • Accepted April 21, 2024
  • Published online July 1, 2024.
Copyright & Usage 
Copyright © 2024 Espay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alberto J. Espay1,
  2. Kasper P. Kepp2 and
  3. Karl Herrup3
  1. 1Department of Neurology, James J. and Joan A. Gardner Family Center for Parkinson’s Disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio 45219
  2. 2Section of Biophysical and Biomedicinal Chemistry, Department of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark
  3. 3Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
  1. Correspondence should be addressed to Karl Herrup at herrup{at}pitt.edu.
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Author contributions

  1. Author contributions: A.J.E., K.P.K., and K.H. wrote the paper.

View Abstract

Disclosures

  • The authors declare no competing financial interests.

  • Dr. A.J.E. has received grant support from the National Institutes of Health and the Michael J Fox Foundation; personal compensation as a consultant/scientific advisory board member for Neuroderm, Amneal Pharmaceuticals, Acadia, Avion Pharmaceuticals, Acorda Therapeutics, Kyowa Kirin, Sunovion, Supernus Pharmaceuticals (formerly, US WorldMeds), and Herantis Pharma; personal honoraria for speakership for Avion Pharmaceuticals, Amneal Pharmaceuticals, and Supernus Pharmaceuticals; and publishing royalties from Lippincott Williams & Wilkins, Cambridge University Press, and Springer. He cofounded REGAIN Therapeutics and is coinventor of the patent “Compositions and methods for treatment and/or prophylaxis of proteinopathies.” He serves on the editorial boards of the Journal of Parkinson's Disease, Journal of Alzheimer's Disease, European Journal of Neurology, Movement Disorders Clinical Practice, and JAMA Neurology. Drs. K.P.K. and K.H. have nothing to disclose.

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Jul 202461050252393
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Total 2026871718487
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eneuro: 11 (7)
eNeuro
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July 2024
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Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
Alberto J. Espay, Kasper P. Kepp, Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; DOI: 10.1523/ENEURO.0319-23.2024

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Lecanemab and Donanemab as Therapies for Alzheimer's Disease: An Illustrated Perspective on the Data
Alberto J. Espay, Kasper P. Kepp, Karl Herrup
eNeuro 1 July 2024, 11 (7) ENEURO.0319-23.2024; DOI: 10.1523/ENEURO.0319-23.2024
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Keywords

  • aducanumab
  • Alzheimer's disease
  • antiamyloid monoclonal antibodies
  • beta-amyloid
  • donanemab
  • lecanemab

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