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Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods

Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman Primates

Usamma Amjad, Jiwon Choi, Daniel J. Gibson, Raymond Murray, Ann M. Graybiel and Helen N. Schwerdt
eNeuro 25 June 2024, 11 (7) ENEURO.0001-24.2024; https://doi.org/10.1523/ENEURO.0001-24.2024
Usamma Amjad
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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Jiwon Choi
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland 20815
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Daniel J. Gibson
3Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Raymond Murray
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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Ann M. Graybiel
3Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Helen N. Schwerdt
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland 20815
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0001-24.2024
PubMed 
38918051
Published By 
Society for Neuroscience
History 
  • Received December 27, 2023
  • Revision received June 3, 2024
  • Accepted June 5, 2024
  • Published online June 25, 2024.
Copyright & Usage 
Copyright © 2024 Amjad et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Usamma Amjad1,
  2. Jiwon Choi1,2,
  3. Daniel J. Gibson3,
  4. Raymond Murray1,
  5. Ann M. Graybiel3 and
  6. Helen N. Schwerdt1,2
  1. 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
  2. 2Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, Maryland 20815
  3. 3Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
  1. Correspondence should be addressed to Helen N. Schwerdt at hes100{at}pitt.edu or Usamma Amjad at usa5{at}pitt.edu.
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Author contributions

  1. Author contributions: U.A. and H.N.S. designed research; U.A. and H.N.S. performed research; D.J.G., A.M.G., and H.N.S. contributed unpublished reagents/analytic tools; U.A., J.C., R.M., and H.N.S. analyzed data; U.A., J.C., and H.N.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Henry F. Hall (Graybiel Laboratory, Massachusetts Institute of Technology) and Dr. Ken-ichi Amemori (Kyoto University) for help with research support and insight, animal care, and surgical procedures.

  • National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS; R00 NS107639 to H.N.S.), the Michael J. Fox Foundation for Parkinson’s Research (MJFF) and the Aligning Science Across Parkinson’s (ASAP) initiative (ASAP-020519 to H.N.S.), NIH/National Institute of Mental Health (P50 MH119467 to A.M.G.), the Army Research Office (W911NF-16-1-0474 to A.M.G.), and Mr. Robert Buxton (to A.M.G.). MJFF administers the ASAP-020519 on behalf of ASAP and itself.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R00 NS107639
  • Michael J. Fox Foundation for Parkinson's Research (MJFF)

    ASAP-020519
  • DOD | USA | AFC | CCDC | Army Research Office (ARO)

    W911NF-16-1-0474
  • HHS | NIH | National Institute of Mental Health (NIMH)

    P50 MH119467
  • Mr. Robert Buxton

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July 2024
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Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman Primates
Usamma Amjad, Jiwon Choi, Daniel J. Gibson, Raymond Murray, Ann M. Graybiel, Helen N. Schwerdt
eNeuro 25 June 2024, 11 (7) ENEURO.0001-24.2024; DOI: 10.1523/ENEURO.0001-24.2024

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Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman Primates
Usamma Amjad, Jiwon Choi, Daniel J. Gibson, Raymond Murray, Ann M. Graybiel, Helen N. Schwerdt
eNeuro 25 June 2024, 11 (7) ENEURO.0001-24.2024; DOI: 10.1523/ENEURO.0001-24.2024
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Keywords

  • dopamine
  • electrophysiology
  • fast-scan cyclic voltammetry
  • multimodal electrochemical and electrical recording
  • neurotransmitters
  • striatum

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