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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Aberrant Functional Connectivity of the Salience Network in Adult Patients with Tic Disorders: A Resting-State fMRI Study

Linda Orth, Johanna Meeh, Delia Leiding, Ute Habel, Irene Neuner and Pegah Sarkheil
eNeuro 14 May 2024, 11 (6) ENEURO.0223-23.2024; https://doi.org/10.1523/ENEURO.0223-23.2024
Linda Orth
1Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany
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  • ORCID record for Linda Orth
Johanna Meeh
2Department of Psychiatry and Psychotherapy, University of Münster, 48149 Münster, Germany
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Delia Leiding
1Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany
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Ute Habel
1Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany
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Irene Neuner
1Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany
3Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, 52428 Jülich, Germany
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Pegah Sarkheil
1Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany
2Department of Psychiatry and Psychotherapy, University of Münster, 48149 Münster, Germany
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    Figure 1.

    SBC results for the seeds’ right insula (higher connectivity), bilateral TPJ, and the ACC and the contrast (patient > control). The red–yellow–white color indicates increased connectivity. The table lists the individual clusters of each seed region in detail with the corresponding MNI coordinates. ACC, anterior cingulate cortex; TPJ, temporoparietal junction; angular g., angular gyrus; cent. operculum, central operculum; front. pole, frontal pole; IFG, inferior frontal gyrus; inf. temp. g., inferior temporal gyrus; MFG, middle frontal gyrus; MTG, middle temporal gyrus; paracing. g., paracingulate gyrus; precent. g., precentral gyrus; SMA, supplementary motor area; SMG, supramarginal gyrus.

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    Figure 2.

    SBC results for the right insula seed in correlation to the YGTSS score. The blue–white coloring indicates decreased connectivity. The table indicates the cluster of the right and left insula seed with the corresponding MNI coordinates. Precent. g., precentral gyrus; SFG, superior frontal gyrus; SMA, supplementary motor area.

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    Table 1.

    Psychotropic medications and comorbidities in the TD group

    n (%)
    Psychotropic medication
     No medication12 (48)
     Antipsychotics + SSRI3 (12)
     Antipsychotics + methylphenidate/atomoxetine2 (8)
     Antipsychotics1 (4)
     Antipsychotics + SSRI + THC1 (4)
     Tiapride1 (4)
     SSRI1 (4)
     SSRI + tiapride + methylphenidate/atomoxetine1 (4)
     THC1 (4)
     Methylphenidate/atomoxetine1 (4)
     Methylphenidate/atomoxetine + THC1 (4)
    Psychiatric comorbidities
     ADHD4 (16)
     OCD3 (12)
     ADHD + depression1 (4)
     OCD + ADHD1 (4)
     OCD + addiction (cannabis)1 (4)
     OCD + depression1 (4)
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    Table 2.

    Clinical scores of TD patients (n = 25)

    MeanSDMinMax
    YGTSS22.98.21042
    GTS-QOL28.118.5169
    PUTS24.95.71033
    BDI-II12.011.0043
    Y–BOCS6.710.2037
    • BDI-II, Beck Depression Inventory-II; GTS-QOL, Gilles de la Tourette Syndrome-Quality of Life Scale; PUTS, Premonitory Urges for Tics Scale; Y–BOCS, Yale–Brown Obsessive–Compulsive Scale; YGTSS, Yale Global Tic Severity Scale.

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eneuro: 11 (6)
eNeuro
Vol. 11, Issue 6
June 2024
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Aberrant Functional Connectivity of the Salience Network in Adult Patients with Tic Disorders: A Resting-State fMRI Study
Linda Orth, Johanna Meeh, Delia Leiding, Ute Habel, Irene Neuner, Pegah Sarkheil
eNeuro 14 May 2024, 11 (6) ENEURO.0223-23.2024; DOI: 10.1523/ENEURO.0223-23.2024

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Aberrant Functional Connectivity of the Salience Network in Adult Patients with Tic Disorders: A Resting-State fMRI Study
Linda Orth, Johanna Meeh, Delia Leiding, Ute Habel, Irene Neuner, Pegah Sarkheil
eNeuro 14 May 2024, 11 (6) ENEURO.0223-23.2024; DOI: 10.1523/ENEURO.0223-23.2024
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Keywords

  • functional connectivity
  • insula
  • non-tic symptoms
  • resting-state fMRI
  • salience network
  • tic disorder

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