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Research ArticleResearch Article: New Research, Cognition and Behavior

The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber

Paul A. S. Sheppard, Charlotte A. Oomen, Timothy J. Bussey and Lisa M. Saksida
eNeuro 6 June 2024, 11 (6) ENEURO.0120-24.2024; https://doi.org/10.1523/ENEURO.0120-24.2024
Paul A. S. Sheppard
1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5B7, Canada
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Charlotte A. Oomen
2Department of Experimental Psychology, University of Cambridge, Cambridge CB2 1TN, United Kingdom
3MRC and Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
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Timothy J. Bussey
2Department of Experimental Psychology, University of Cambridge, Cambridge CB2 1TN, United Kingdom
3MRC and Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
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Lisa M. Saksida
2Department of Experimental Psychology, University of Cambridge, Cambridge CB2 1TN, United Kingdom
3MRC and Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0120-24.2024
PubMed 
38844347
Published By 
Society for Neuroscience
History 
  • Received March 18, 2024
  • Revision received May 28, 2024
  • Accepted May 30, 2024
  • Published online June 6, 2024.
Copyright & Usage 
Copyright © 2024 Sheppard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Paul A. S. Sheppard1,
  2. Charlotte A. Oomen2,3,
  3. Timothy J. Bussey2,3 and
  4. Lisa M. Saksida2,3
  1. 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5B7, Canada
  2. 2Department of Experimental Psychology, University of Cambridge, Cambridge CB2 1TN, United Kingdom
  3. 3MRC and Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
  1. Correspondence should be addressed to Paul A. S. Sheppard at psheppa5{at}uwo.ca.
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Author contributions

  1. Author contributions: C.A.O., T.J.B., and L.M.S. designed research; C.A.O. performed research; P.A.S.S. analyzed data; P.A.S.S. and T.J.B. wrote the paper.

Disclosures

  • T.J.B. and L.M.S. have established a series of targeted cognitive tests for animals, administered via touchscreen within a custom environment known as the “Bussey–Saksida touchscreen chamber.” Cambridge Enterprise, the technology transfer office of the University of Cambridge, supported the commercialization of the Bussey–Saksida chamber, culminating in a license to Campden Instruments. Any financial compensation received from the commercialization of the technology is fully invested in further touchscreen development and/or maintenance. The authors declare no competing financial interests.

  • This work was funded by the EU Innovative Medicines Initiative (Ref. Number: 115008), Janssen Pharmaceuticals, and Natural Sciences and Engineering Research Council of Canada (RGPIN-2019-06087). The authors thank the members of the Translational Cognitive Neuroscience Lab for their help with behavioral testing and David Theobald for the assistance with surgeries and perfusions. Figure 1 was made using BioRender.com.

  • T.J.B.’s and L.M.S.’s present address: Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry and Robarts Research Institute, Western University, London, ON, Canada

Funding

  • Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)

    RGPIN-2019-06087
  • EU Innovative Medicines Initiative

    115008
  • Auris | J&J | Janssen UK (Janssen-Cilag Limited)

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  • You are viewing the most recent version of this article.
  • previous version (June 06, 2024).

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The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber
Paul A. S. Sheppard, Charlotte A. Oomen, Timothy J. Bussey, Lisa M. Saksida
eNeuro 6 June 2024, 11 (6) ENEURO.0120-24.2024; DOI: 10.1523/ENEURO.0120-24.2024

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The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber
Paul A. S. Sheppard, Charlotte A. Oomen, Timothy J. Bussey, Lisa M. Saksida
eNeuro 6 June 2024, 11 (6) ENEURO.0120-24.2024; DOI: 10.1523/ENEURO.0120-24.2024
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Keywords

  • associative learning
  • paired-associates learning
  • trial-unique nonmatching-to-location
  • visual discrimination
  • working memory

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