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Research ArticleResearch Article: New Research, Cognition and Behavior

Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling

Xuyang Zhang, Qingzhu Zhang, Qian Zhang, Haomiao Wang, Yi Yin, Huanhuan Li, Qianying Huang, Chao Guo, Jun Zhong, Tengyuan Zhou, Yujie Chen, Zhi Chen, Qiao Shan and Rong Hu
eNeuro 10 May 2024, 11 (6) ENEURO.0021-24.2024; https://doi.org/10.1523/ENEURO.0021-24.2024
Xuyang Zhang
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Qingzhu Zhang
2Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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Qian Zhang
3Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
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Haomiao Wang
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Yi Yin
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Huanhuan Li
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Qianying Huang
3Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
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Chao Guo
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Jun Zhong
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Tengyuan Zhou
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Yujie Chen
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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  • ORCID record for Yujie Chen
Zhi Chen
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Qiao Shan
2Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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Rong Hu
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0021-24.2024
PubMed 
38729764
Published By 
Society for Neuroscience
History 
  • Received January 17, 2024
  • Revision received April 28, 2024
  • Accepted April 29, 2024
  • Published online May 10, 2024.
Copyright & Usage 
Copyright © 2024 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Xuyang Zhang1,*,
  2. Qingzhu Zhang2,*,
  3. Qian Zhang3,
  4. Haomiao Wang1,
  5. Yi Yin1,
  6. Huanhuan Li1,
  7. Qianying Huang3,
  8. Chao Guo1,
  9. Jun Zhong1,
  10. Tengyuan Zhou1,
  11. Yujie Chen1,
  12. Zhi Chen1,
  13. Qiao Shan2 and
  14. Rong Hu1
  1. 1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China
  2. 2Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  3. 3Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
  1. Correspondence should be addressed to Rong Hu at huchrong{at}tmmu.edu.cn.
View Full Text

Author contributions

  1. Author contributions: R.H. designed research; X.Z., Qingzhu Zhang, H.L., and C.G. performed research; Qian Zhang, H.W., Y.Y., Q.H., C.G., J.Z., T.Z., Y.C., Z.C., and Q.S. contributed unpublished reagents/analytic tools; X.Z., Qingzhu Zhang, Qian Zhang, H.W., Y.Y., H.L., Q.H., J.Z., T.Z., Y.C., Z.C., and Q.S. analyzed data; X.Z. and R.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from the National Natural Science Foundation of China (81671228 to R.H.), Chongqing Municipal Science Fund for Distinguished Young Scholars (cstc2019jcyjjqX0030 to R.H.), and National College Students’ Innovation and Entrepreneurship Training Program (202290031034 to H.W.).

  • ↵*X.Z. and Qingzhu Zhang contributed equally to this work.

Funding

  • National Natural Science Foundation of China

    81671228
  • Chongqing Municipal Science Fund for Distinguished Young Scholars

    cstc2019jcyjjqX0030
  • MOE | National College Students Innovation and Entrepreneurship Training Program (全国大学生创新创业培训计划)

    202290031034

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 10, 2024).

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May 20242830110
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Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling
Xuyang Zhang, Qingzhu Zhang, Qian Zhang, Haomiao Wang, Yi Yin, Huanhuan Li, Qianying Huang, Chao Guo, Jun Zhong, Tengyuan Zhou, Yujie Chen, Zhi Chen, Qiao Shan, Rong Hu
eNeuro 10 May 2024, 11 (6) ENEURO.0021-24.2024; DOI: 10.1523/ENEURO.0021-24.2024

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Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling
Xuyang Zhang, Qingzhu Zhang, Qian Zhang, Haomiao Wang, Yi Yin, Huanhuan Li, Qianying Huang, Chao Guo, Jun Zhong, Tengyuan Zhou, Yujie Chen, Zhi Chen, Qiao Shan, Rong Hu
eNeuro 10 May 2024, 11 (6) ENEURO.0021-24.2024; DOI: 10.1523/ENEURO.0021-24.2024
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Keywords

  • cognition
  • hemorrhagic stroke
  • neurogenesis
  • Pten
  • tetrahydrofolate

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