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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice

Alyssa B. Danis, Ashlynn A. Gallagher, Ashley N. Anderson, Arielle Isakharov, Kathleen A. Beeson and Eric Schnell
eNeuro 15 May 2024, 11 (5) ENEURO.0486-23.2024; https://doi.org/10.1523/ENEURO.0486-23.2024
Alyssa B. Danis
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
2Research and Development Service, Portland VA Health Care System, Portland, Oregon 97239
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Ashlynn A. Gallagher
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
2Research and Development Service, Portland VA Health Care System, Portland, Oregon 97239
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  • ORCID record for Ashlynn A. Gallagher
Ashley N. Anderson
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
2Research and Development Service, Portland VA Health Care System, Portland, Oregon 97239
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Arielle Isakharov
3Neuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239
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  • ORCID record for Arielle Isakharov
Kathleen A. Beeson
3Neuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239
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  • ORCID record for Kathleen A. Beeson
Eric Schnell
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
2Research and Development Service, Portland VA Health Care System, Portland, Oregon 97239
3Neuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0486-23.2024
PubMed 
38749701
Published By 
Society for Neuroscience
History 
  • Received November 21, 2023
  • Revision received April 8, 2024
  • Accepted April 10, 2024
  • Published online May 15, 2024.
Copyright & Usage 
Copyright © 2024 Danis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alyssa B. Danis1,2,
  2. Ashlynn A. Gallagher1,2,
  3. Ashley N. Anderson1,2,
  4. Arielle Isakharov3,
  5. Kathleen A. Beeson3 and
  6. Eric Schnell1,2,3
  1. 1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239
  2. 2Research and Development Service, Portland VA Health Care System, Portland, Oregon 97239
  3. 3Neuroscience Graduate Program, Oregon Health & Science University, Portland, Oregon 97239
  1. Correspondence should be addressed to Eric Schnell at schneler{at}ohsu.edu.
View Full Text

Author contributions

  1. Author contributions: E.S. designed research; A.B.D., A.A.G., A.N.A., A.I., K.A.B., and E.S. performed research; A.B.D., A.A.G., A.N.A., and E.S. analyzed data; A.B.D. and E.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Gary Westbrook and his lab members for helpful discussions of our data, Drs. Sergey Ivanov and Lino Tessarollo for generously providing mutant mice, and the members of the Schnell Lab for the feedback and support. This work was funded by National Institutes of Health Grants R01NS126247 (E.S.) and R21NS102948 (Ines Koerner/E.S.), Department of Defense W81XWH-18-1-0598 (E.S.), and Veterans Affairs I01-BX004938 (E.S.). The contents of this manuscript do not represent the views of the US Department of Veterans Affairs or the US government.

Funding

  • NIH

    R01NS126247; R21NS102948
  • DOD

    W81XWH-18-1-0598
  • VA

    I01-BX004938

Online Impact

 

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Article usage: May 2024 to April 2026

AbstractFullPdf
May 2024333704229
Jun 20243219382
Jul 20242711723
Aug 20242113754
Sep 2024209246
Oct 2024128750
Nov 2024119434
Dec 202477040
Total 20244631494558
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Apr 202599838
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Jun 202597123
Jul 2025910748
Aug 202538726
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Feb 2026619231
Mar 20261013435
Apr 2026613160
Total 202631579158
Total59133451109
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eneuro: 11 (5)
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May 2024
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Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice
Alyssa B. Danis, Ashlynn A. Gallagher, Ashley N. Anderson, Arielle Isakharov, Kathleen A. Beeson, Eric Schnell
eNeuro 15 May 2024, 11 (5) ENEURO.0486-23.2024; DOI: 10.1523/ENEURO.0486-23.2024

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Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice
Alyssa B. Danis, Ashlynn A. Gallagher, Ashley N. Anderson, Arielle Isakharov, Kathleen A. Beeson, Eric Schnell
eNeuro 15 May 2024, 11 (5) ENEURO.0486-23.2024; DOI: 10.1523/ENEURO.0486-23.2024
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Keywords

  • alpha-2-delta
  • calcium channels
  • dentate gyrus
  • epilepsy
  • hippocampus

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