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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis

Alicia M. Hall, Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Kevin Chen, Yuncai Chen and Tallie Z. Baram
eNeuro 19 April 2024, 11 (5) ENEURO.0006-24.2024; https://doi.org/10.1523/ENEURO.0006-24.2024
Alicia M. Hall
1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
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Noriko Kamei
2Department of Anatomy and Neurobiology, University of California-Irvine, Irvine, California 92697
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Manlin Shao
1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
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Hyun-Seung Mun
2Department of Anatomy and Neurobiology, University of California-Irvine, Irvine, California 92697
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Kevin Chen
1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
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Yuncai Chen
1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
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Tallie Z. Baram
1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
2Department of Anatomy and Neurobiology, University of California-Irvine, Irvine, California 92697
3Department of Neurology, University of California-Irvine, Irvine, California 92697
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0006-24.2024
PubMed 
38641413
Published By 
Society for Neuroscience
History 
  • Received December 26, 2023
  • Revision received April 8, 2024
  • Accepted April 15, 2024
  • Published online April 19, 2024.
Copyright & Usage 
Copyright © 2024 Hall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alicia M. Hall1,
  2. Noriko Kamei2,
  3. Manlin Shao1,
  4. Hyun-Seung Mun2,
  5. Kevin Chen1,
  6. Yuncai Chen1 and
  7. Tallie Z. Baram1,2,3
  1. 1Department of Pediatrics, University of California-Irvine, Irvine, California 92697
  2. 2Department of Anatomy and Neurobiology, University of California-Irvine, Irvine, California 92697
  3. 3Department of Neurology, University of California-Irvine, Irvine, California 92697
  1. Correspondence should be addressed to Tallie Z. Baram at tallie{at}uci.edu.
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Author contributions

  1. Author contributions: A.M.H. and T.Z.B. designed research; A.M.H., N.K., and M.S. performed research; Y.C. contributed unpublished reagents/analytic tools; A.M.H., N.K., M.S., H.-S.M., K.C., and T.Z.B. analyzed data; A.M.H., K.C., and T.Z.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Jennifer Daglian, Maggie Roa Tiffany (My-Tien) Nguyen, and Gissell A. Sanchez for their technical support. This work was supported by National Institutes of Health Grants NS108296 and NS35439.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS108296; NS35438

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Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis
Alicia M. Hall, Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Kevin Chen, Yuncai Chen, Tallie Z. Baram
eNeuro 19 April 2024, 11 (5) ENEURO.0006-24.2024; DOI: 10.1523/ENEURO.0006-24.2024

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Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis
Alicia M. Hall, Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Kevin Chen, Yuncai Chen, Tallie Z. Baram
eNeuro 19 April 2024, 11 (5) ENEURO.0006-24.2024; DOI: 10.1523/ENEURO.0006-24.2024
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Keywords

  • epigenetic
  • epileptogenesis
  • kainic acid
  • REST/NRSF
  • status epilepticus
  • transcription factor

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