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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance

Yuri Hirayama, Ha Pham Ngoc Le, Hirofumi Hashimoto, Itsuko Ishii, Schuichi Koizumi and Naohiko Anzai
eNeuro 11 April 2024, 11 (4) ENEURO.0494-23.2024; https://doi.org/10.1523/ENEURO.0494-23.2024
Yuri Hirayama
1Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
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Ha Pham Ngoc Le
2Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan
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Hirofumi Hashimoto
1Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
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Itsuko Ishii
3Division of Pharmacy, Chiba University Hospital, Chiba 260-8677, Japan
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Schuichi Koizumi
2Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan
4GLIA Center, University of Yamanashi, Yamanashi 409-3898, Japan
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  • ORCID record for Schuichi Koizumi
Naohiko Anzai
1Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0494-23.2024
PubMed 
38604775
Published By 
Society for Neuroscience
History 
  • Received November 26, 2023
  • Revision received March 27, 2024
  • Accepted April 5, 2024
  • Published online April 11, 2024.
Copyright & Usage 
Copyright © 2024 Hirayama et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yuri Hirayama1,
  2. Ha Pham Ngoc Le2,
  3. Hirofumi Hashimoto1,
  4. Itsuko Ishii3,
  5. Schuichi Koizumi2,4 and
  6. Naohiko Anzai1
  1. 1Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
  2. 2Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan
  3. 3Division of Pharmacy, Chiba University Hospital, Chiba 260-8677, Japan
  4. 4GLIA Center, University of Yamanashi, Yamanashi 409-3898, Japan
  1. Correspondence should be addressed to Yuri Hirayama at yhirayama{at}chiba-u.jp or Naohiko Anzai at afga5078{at}faculty.gs.chiba-u.jp.
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Author contributions

  1. Author contributions: Y.H., S.K., and N.A. designed research; Y.H. and H.P.N.L. performed research; Y.H., H.H., I.I., S.K., and N.A. analyzed data; Y.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Grant sponsors: This study was supported by Japan Society for the Promotion of Science Kakenhi 22K06853 (Y.H.), 20H05902 (S.K.), 21H04786 (S.K.), and 21K19309 (S.K.); the Uehara Memorial Foundation (Y.H.); the Astellas Foundation for Research on Metabolic Disorders (Y.H.); and The Naito Foundation (Y.H.). We thank the members of the Anzai and Koizumi labs for their helpful comments and discussion. We also thank Drs. Enaida (Saga University) and Notomi (Kyushu University) for providing the P2X7 receptor knock-out mice. We thank Bronwen Gardner, PhD, from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Funding

  • JSPS KAKENHI

    22K06853; 20H05902; 21H04786; 21K19309
  • Uehara Memorial Foundation (UMF)

  • Astellas Foundation for Research on Metabolic Disorders

  • Naito Foundation (内藤記念科学振興財団)

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  • previous version (April 11, 2024).

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Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance
Yuri Hirayama, Ha Pham Ngoc Le, Hirofumi Hashimoto, Itsuko Ishii, Schuichi Koizumi, Naohiko Anzai
eNeuro 11 April 2024, 11 (4) ENEURO.0494-23.2024; DOI: 10.1523/ENEURO.0494-23.2024

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Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance
Yuri Hirayama, Ha Pham Ngoc Le, Hirofumi Hashimoto, Itsuko Ishii, Schuichi Koizumi, Naohiko Anzai
eNeuro 11 April 2024, 11 (4) ENEURO.0494-23.2024; DOI: 10.1523/ENEURO.0494-23.2024
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Keywords

  • astrocytes
  • CD147
  • ischemic tolerance
  • lactate
  • P2X7 receptor

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